ArticleAnnals of clinical microbiology and antimicrobials2010
Dissemination of multidrug resistant Acinetobacter baumannii in various hospitals of Antananarivo Madagascar.
Article in Annals of clinical microbiology and antimicrobials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comprehensive analysis of antimicrobial resistance in the Southwest Indian Ocean: focus on WHO critical and high priority pathogens.Frontiers in public health · 2024Pooled it
- Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis.PloS one · 2017Pooled it
- The spread of carbapenemase-producing bacteria in Africa: a systematic review.The Journal of antimicrobial chemotherapy · 2015Pooled it
- Whole genome analysis of carbapenem resistantNew microbes and new infections · 2026Article
- The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden.Antibiotics (Basel, Switzerland) · 2024Review
- ESBL-Type and AmpC-Type Beta-Lactamases in Third Generation Cephalosporin-ResistantAnimals : an open access journal from MDPI · 2024Article
- Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study.Scientific reports · 2023Article
- Carbapenem resistance inAIMS microbiology · 2023Review
- Sequence-Specific Electrochemical Genosensor for Rapid Detection ofMicroorganisms · 2022Article
- Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii.Scientific reports · 2021Article
- Evaluating the frequency of carbapenem and aminoglycoside resistance genes among clinical isolates ofNew microbes and new infections · 2020Article
- Distribution of carbapenemase genes in clinical isolates ofThe Indian journal of medical research · 2020Article
- Antimicrobial resistance patterns and their encoding genes among clinical isolates ofMethodsX · 2020Article
- Phenotypic and molecular characterisations of carbapenem-resistantAntimicrobial resistance and infection control · 2019Article
- Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study.Annals of clinical microbiology and antimicrobials · 2018Observational
- Distribution of Class D Carbapenemase and Extended-Spectrum β-Lactamase Genes amongJournal of clinical and diagnostic research : JCDR · 2017Article
- Review of Antibiotic Resistance in the Indian Ocean Commission: A Human and Animal Health Issue.Frontiers in public health · 2017Review
- Antimicrobial effects ofIranian journal of microbiology · 2016Article
- Characterization of Oxacillinase and Metallo-β-Lactamas Genes and Molecular Typing of Clinical Isolates of Acinetobacter baumannii in Ahvaz, South-West of Iran.Jundishapur journal of microbiology · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports the dissemination of multidrug-resistant (MDR) OXA-23-producing Acinetobacter baumannii clones in hospitals in Antananarivo, Madagascar. A total of 53 carbapenem-resistant A. baumannii isolates were obtained from September 2006 to March 2009 in five hospitals. These resistant strains represent 44% of all A. baumannii isolates. The double disk synergy test was performed to screen for production of metallo-beta-lactamases. Polymerase chain reaction (PCR) and DNA sequencing were performed for the detection of bla(AmpC), bla(OXA-51),bla(OXA-23), bla(OXA-24), bla(IMP), bla(VIM). The presence of the insertion sequence ISAba1 relative to blaOXA-23 and blaOXA-51 was assessed by PCR. Isolates were typed by Rep-PCR. All the isolates were MDR and produced the OXA-23 carbapenemase, which was confirmed by sequencing. PCR analysis for AmpC and OXA-51 gave positive results for all strains studied. No isolates produced metallo-beta-lactamases. In all isolates ISAba1 laid upstream of blaOXA-23. The A. baumannii isolates were separated into two genotypes; genotype A had a higher prevalence (41 strains) than genotype B (12 strains). Genotype A was present in four hospitals, whilst genotype B had spread in two hospitals. The high frequency of MDR OXA-23-producing A. baumannii in various hospitals in Antananarivo is curious since carbapenems are not available in Madagascar, but it emphasises the need for infection control procedures and strict adherence to them to prevent the spread of these resistant organisms in Antananarivo and also the need to control the use of carbapenems in the future.
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