ArticleParasite immunology2010
Strain variation in early innate cytokine induction by Plasmodium falciparum.
Article in Parasite immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.PLoS pathogens · 2012Trial
- Asymptomatic carriage of Plasmodium falciparum in children living in a hyperendemic area occurs independently of IgG responses but is associated with a balanced inflammatory cytokine ratio.Malaria journal · 2024Article
- Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance.Nature communications · 2021Article
- Human Microglia Respond to Malaria-Induced Extracellular Vesicles.Pathogens (Basel, Switzerland) · 2019Article
- Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.Malaria journal · 2014Observational
- Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections.Memorias do Instituto Oswaldo Cruz · 2014Article
- A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Selection of Plasmodium falciparum parasites for cytoadhesion to human brain endothelial cells.Journal of visualized experiments : JoVE · 2012Article
- Article
- Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses.Nature communications · 2011Article
- Plasmodium falciparum-infected erythrocytes and beta-hematin induce partial maturation of human dendritic cells and increase their migratory ability in response to lymphoid chemokines.Infection and immunity · 2011Article
- Article
- Consequences of immunopathology for pathogen virulence evolution and public health: malaria as a case study.Evolutionary applications · 2011Article
- Article
- Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work has shown that human donors vary in the magnitude and pattern of cytokines induced when peripheral blood mononuclear cells (PBMCs) are co-cultured with Plasmodium falciparum-infected erythrocytes. Whether P. falciparum strains vary in their ability to induce cytokines has not been studied in detail and is an important question, because variation in cytokine induction could affect parasite virulence and patterns of clinical disease. We investigated the early inflammatory cytokine response to four P. falciparum laboratory strains and five field isolates. Initial studies showed that parasite strain, parasitaemia and PBMC donor all had significant effects on the magnitude of pro-inflammatory cytokine responses (IFN-gamma, GM-CSF, IL-1 beta, TNF-alpha, IL-6, P < 0.005 in all cases). However, we noticed that the most highly inducing parasite strain consistently reached schizont rupture more rapidly than the other strains. When timing of schizont rupture was taken into account, parasite strains no longer differed in their cytokine induction (P = 0.383), although donor effects remained significant (P < 0.001). These data do not support the hypothesis that P. falciparum strains vary in induction of early innate cytokine responses from PBMCs, and instead are consistent with the suggestion that conserved parasite products such as haemozoin or GPI-anchors are the parasite-derived stimuli for cytokine induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.