ArticleExperimental dermatology2010
The cycling hair follicle as an ideal systems biology research model.
Article in Experimental dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- COCH Expression in the Hair Follicle Microenvironment Is Associated With Cortical Disulfide Bonding and Tensile Resistance in Aging Hair.Experimental dermatology · 2026Article
- Nanotechnology-Based Strategies for Hair Regeneration: Mechanistic Insights and Translational Perspectives for Androgenetic Alopecia.Biomedicines · 2026Review
- Analysis of Changes in Scalp Skin Thickness According to Age and Sex Based on Ultrasonography and Histometry.Archives of plastic surgery · 2025Article
- Hair Growth-Promoting Effects of Rosehip (Preventive nutrition and food science · 2023Article
- Hair Follicles as a Critical Model for Monitoring the Circadian Clock.International journal of molecular sciences · 2023Review
- DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration.International journal of molecular sciences · 2022Article
- Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics.Frontiers in cell and developmental biology · 2022Review
- The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages.Biological reviews of the Cambridge Philosophical Society · 2021Article
- The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives.Frontiers in cell and developmental biology · 2021Review
- The microfollicle: a model of the human hair follicle for in vitro studies.In vitro cellular & developmental biology. Animal · 2020Article
- Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock.Nature communications · 2020Article
- Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?Experimental dermatology · 2020Review
- Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research.The Journal of investigative dermatology · 2020Article
- Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla CellsFrontiers in cell and developmental biology · 2020Article
- Understanding skin morphogenesis across developmental, regenerative and evolutionary levels.Experimental dermatology · 2019Article
- Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice andFrontiers in pharmacology · 2019Article
- Article
- Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus).BMC genomics · 2017Article
- Article
- Macrophages induce AKT/β-catenin-dependent Lgr5Nature communications · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In the postgenomic era, systems biology has rapidly emerged as an exciting field predicted to enhance the molecular understanding of complex biological systems by the use of quantitative experimental and mathematical approaches. Systems biology studies how the components of a biological system (e.g. genes, transcripts, proteins, metabolites) interact to bring about defined biological function or dysfunction. Living systems may be divided into five dimensions of complexity: (i) molecular; (ii) structural; (iii) temporal; (iv) abstraction and emergence; and (v) algorithmic. Understanding the details of these dimensions in living systems is the challenge that systems biology aims to address. Here, we argue that the hair follicle (HF), one of the signature features of mammals, is a perfect and clinically relevant model for systems biology research. The HF represents a stem cell-rich, essentially autonomous mini-organ, whose cyclic transformations follow a hypothetical intrafollicular "hair cycle clock" (HCC). This prototypic neuroectodermal-mesodermal interaction system, at the cross-roads of systems and chronobiology, encompasses various levels of complexity as it is subject to both intrafollicular and extrafollicular inputs (e.g. intracutaneous timing mechanisms with neural and systemic stimuli). Exploring how the cycling HF addresses the five dimensions of living systems, we argue that a systems biology approach to the study of hair growth and cycling, in man and mice, has great translational medicine potential. Namely, the easily accessible human HF invites preclinical and clinical testing of novel hypotheses generated with this approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.