← GLP-1 receptor agonists × body weight & composition

TrialDiabetes, obesity & metabolism2010

Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes.

B W Bode et al.PubMed ↗Full text ↗Publisher ↗

A later paper about NCT00294723. The trial’s primary report, PMID 18819705, speaks for it on the map; the numbers here are shown and do not vote.

  • Liraglutide 1.8 mglooks good hereLower feel overweight.Randomised, small.
  • Liraglutide (combined groups)looks good hereLower report weight concern.Randomised, small.

What the trial testedrandomised · 732 people · 2010

Randomised vs glimepiride 8 mg

Probably lowered feel overweight

Doesn’t vote: a later paper about the trial

−52%−67% to −30%

liraglutide 1.8 mg vs glimepiride 8 mg

Bigger than 8 in 10 on the map

As reported

OR 0.48, 95% CI 0.33–0.70

Randomised vs glimepiride 8 mg

Probably lowered report weight concern

Doesn’t vote: a later paper about the trial

−45%−59% to −27%

liraglutide (combined groups) vs glimepiride 8 mg

Bigger than 8 in 10 on the map

As reported

OR 0.55, 95% CI 0.41–0.73

Who was studied, and how

746people in the Liraglutide Effect and Action in Diabetes trial, from 2006
732of them with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

liraglutide 1.8 mg
glimepiride 8 mg

Probably lowered feel overweight−52%

randomised

The trial randomly assignedassigned by chance

liraglutide (combined groups)
glimepiride 8 mg

Probably lowered report weight concern−45%

randomised

the abstract, start to end

… to feel overweight [odds ratio (OR) 0.48; 95% confidence interval (CI): …

… less likely to report weight concern (OR 0.55, 95% CI: 0.41-0.73).

← favours treatmentfavours comparator →
could be chance
Feel overweightliraglutide 1.8 mg vs glimepiride 8 mg
OR 0.480.33–0.70
Report weight concernliraglutide (combined groups) vs glimepiride 8 mg
OR 0.550.41–0.73
GLP-1 receptor agonistsBody weight & composition
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33 papers cite it

2010
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this paperpooled ittrialcites it

The trial

NCT00294723phase 3746 enrolled2006a later paper about it
Full record →Abstract, authors, funding and every citing paper · PMID 20590735