Evidence map›Paper›PMID 20590534›Full record

ReviewAnnals of the New York Academy of Sciences2010

Reflex conditioning: a new strategy for improving motor function after spinal cord injury.

Xiang Yang Chen, Yi Chen, Yu Wang, Aiko Thompson, Jonathan S Carp, Richard L Segal, Jonathan R Wolpaw

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Relationship Between Spinal Reflexes and Spastic Movement Disorders.Physical medicine and rehabilitation clinics of North America · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Neural adaptations to electrical stimulation strength training.European journal of applied physiology · 2011
    Review
  7. Biological basis of exercise-based treatments: spinal cord injury.PM & R : the journal of injury, function, and rehabilitation · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiang Yang ChenNew York State Department of Health, Wadsworth Center, Albany, New York 12201-0509, USA. chenx@wadsworth.org
Yi Chen
Yu Wang
Aiko Thompson
Jonathan S Carp
Richard L Segal
Jonathan R Wolpaw

Funding

SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITYR01HD036020 · NICHD · WADSWORTH CENTER · PI CHEN, XIANG YANG · 1997 to 2012
$3.2M
ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEXR01NS022189 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 1985 to 2012
$3.1M
Spinal Reflex Conditioning and LocomotionR01NS061823 · NINDS · WADSWORTH CENTER · PI CHEN, XIANG YANG, WOLPAW, JONATHAN RICKEL · 2008 to 2011
$1.3M
NICHD NIH HHS HD36020NICHD NIH HHS R01 HD036020NINDS NIH HHS NS061823NINDS NIH HHS NS22189NINDS NIH HHS R01 NS022189NINDS NIH HHS R01 NS061823
6 · The paper itself

Abstract

Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.

Indexed as

AnimalsHumansLocomotionMotor SkillsRatsRecovery of FunctionReflexSpinal Cord Injuries

Identifiers

PMID20590534
PMCPMC2925434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.