Trial reportSurgical endoscopy2011
Effects of preemptive analgesia in laparoscopic cholecystectomy: a double-blind randomized controlled trial.
Trial report in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic cholecystectomy.The Cochrane database of systematic reviews · 2014Pooled it
- Comparison of preemptive and preventive intravenous acetaminophen on opioid consumption in pediatrics undergoing posterior spinal fusion surgery: a randomized controlled trial.Korean journal of anesthesiology · 2024Trial
- A Multimodal Analgesic Protocol Reduces Opioid-Related Adverse Events and Improves Patient Outcomes in Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2017Trial
- Combination of etoricoxib and low-pressure pneumoperitoneum versus standard treatment for the management of pain after laparoscopic cholecystectomy: a randomized controlled trial.Surgical endoscopy · 2016Trial
- Multiple-, but not single-, dose of parecoxib reduces shoulder pain after gynecologic laparoscopy.International journal of medical sciences · 2012Trial
- The effect of preemptive analgesia on postoperative pain in patients with high neutrophil-to-lymphocyte ratios: a prospective, randomized, double-blind, placebo-controlled trial.Annals of surgical treatment and research · 2025Article
- Clinical effect of preoperative intravenous non-steroidal anti-inflammatory drugs on relief of postoperative pain in patients after laparoscopic cholecystectomy: Intravenous ibuprofen vs. intravenous ketorolac.Annals of hepato-biliary-pancreatic surgery · 2022Article
- To drain or not to drain: the association between residual intraperitoneal gas and post-laparoscopic shoulder pain for laparoscopic cholecystectomy.Scientific reports · 2021Observational
- Preemptive Analgesia in Total Knee Arthroplasty: Comparing the Effects of Single Dose Combining Celecoxib with Pregabalin and Repetition Dose Combining Celecoxib with Pregabalin: Double-Blind Controlled Clinical Trial.Pain research and treatment · 2018Article
- Predictive Factors for a Long Hospital Stay in Patients Undergoing Laparoscopic Cholecystectomy.International journal of hepatology · 2017Article
- Post-Operative Pain Management in Patients Undergoing Robotic Urological Surgery.Current urology · 2016Review
- Parecoxib increases muscle pain threshold and relieves shoulder pain after gynecologic laparoscopy: a randomized controlled trial.Journal of pain research · 2016Article
- Review
- Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy: A prospective randomized, placebo-controlled trial.Journal of anaesthesiology, clinical pharmacology · 2013Article
- Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the effect of preemptive etoricoxib compared with placebo in laparoscopic cholecystectomy.
methodsThis randomized, double-blind, placebo-controlled study enrolled 120 patients requiring elective laparoscopic cholecystectomy. The patients were randomized to receive either etoricoxib 120 mg plus diazepam or placebo plus diazepam. Postoperatively, the visual analog score (VAS) for pain, the rescue morphine requirement, and the side effects were recorded.
resultsBetween February 2006 and September 2007, 120 patients were enrolled in the study. The demographic data between two groups were similar except for mean age. The mean age of the placebo group was younger (p = 0.007). There were no significant differences in bleeding tendency rating scores, duration times between fentanyl and rescue morphine, number of rescue morphine doses, or length of postoperative hospital stay. But the number of oral analgesic drug usages was significantly less in the etoricoxib group (p = 0.006). The postoperative VAS was lower in the etoricoxib group at hours 10 (p = 0.023), 14 (p = 0.045), and 26 (p = 0.011), and the average VAS also was significantly less in the etoricoxib group (p = 0.013). The two groups did not differ significantly in terms of postoperative shoulder pain (p = 0.065). According to the verbal rating scale, the incidence of postoperative nausea and vomiting did not differ significantly between the two groups (p = 0.797), nor did the drug side effects or treatment complications.
conclusionThe authors recommend using etoricoxib as a preemptive analgesia to reduce postoperative pain after laparoscopic cholecystectomy.
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