ArticleEuropean archives of psychiatry and clinical neuroscience2011
Childhood adversity and chronicity of mood disorders.
Article in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Psychological Mediators of the Association Between Childhood Emotional Abuse and Depression: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Trial
- Differential Methylation by Early Life Adversity in the Future of Families Child Wellbeing Study.bioRxiv : the preprint server for biology · 2026Article
- Group music therapy with songwriting for adult patients with long-term depression (SYNCHRONY study): a feasibility and acceptability study of the intervention and parallel randomised controlled trial design with wait-list control and nested process evaluation.Pilot and feasibility studies · 2023Article
- Borderline Personality Pathology in Major Depressive Disorder, Bipolar I and II Disorder, and Its Relationship With Childhood Trauma.Psychiatry investigation · 2022Article
- A Study of Psychological Factors Associated with Functional Gastrointestinal Disorders and Use of Health Care.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- The Interaction of Adverse Childhood Experiences and Resiliency on the Outcome of Depression Among Children and Youth, 8-17 year olds.Child abuse & neglect · 2020Article
- The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress.Neuropsychiatric disease and treatment · 2020Review
- Reduced fractional anisotropy in depressed patients due to childhood maltreatment rather than diagnosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The Dutch Bipolar Offspring Study: Cognitive Development and Psychopathology.Journal of abnormal child psychology · 2019Article
- Childhood Adversity Impairs Theory of Mind Abilities in Adult Patients With Major Depressive Disorder.Frontiers in psychiatry · 2019Article
- Attention Deficit Hyperactivity Disorder And Borderline Personality Disorder In Adults: A Review Of Their Links And Risks.Neuropsychiatric disease and treatment · 2019Review
- Articulation and testing of a personality-centred model of psychopathology: evidence from a longitudinal community study over 30 years.European archives of psychiatry and clinical neuroscience · 2018Article
- Association Between Early Life Adversity and Risk for Poor Emotional and Physical Health in Adolescence: A Putative Mechanistic Neurodevelopmental Pathway.JAMA pediatrics · 2017Article
- Childhood Adversities and Depression in Adulthood: Current Findings and Future Directions.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2017Article
- Understanding gene × early adversity interactions: possibilities for insight in the biology of psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2017Article
- Childhood neglect predicts the course of major depression in a tertiary care sample: a follow-up study.BMC psychiatry · 2017Article
- Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder.Epidemiology and psychiatric sciences · 2017Review
- Testing a machine-learning algorithm to predict the persistence and severity of major depressive disorder from baseline self-reports.Molecular psychiatry · 2016Article
- Course of depression in a 10-year prospective study: Evidence for qualitatively distinct subgroups.Journal of abnormal psychology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the potential impact of early childhood problems on the chronicity of mood disorders. A representative cohort from the population was prospectively studied from ages 19/20 to 39/40. Unipolar (UP) and bipolar disorders (BP) were operationally defined applying broad Zurich criteria for bipolarity. Chronicity required the presence of symptoms for more days than not over 2 years prior to an interview, or almost daily occurrence for 1 year. A family history and a history of childhood problems were taken at ages 27/28 and 29/30. Data include the first of multiple self-assessments with the Symptom-Checklist-90 R at age 19/20, and mastery and self-esteem assessed 1 year later. A factor analysis of childhood problems yielded two factors: family problems and conduct problems. Sexual trauma, which did not load on either factor, and conduct problems were unrelated to chronicity of UP or BP or both together. In contrast, childhood family problems increased the risk of chronicity by a factor of 1.7. An anxious personality in childhood and low self-esteem and mastery in early adulthood were also associated with chronicity. Childhood family problems are strong risk factors for the chronicity of mood disorders (UP and BP). The risk may be mediated partly by anxious personality traits, poor coping and low self-esteem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.