Evidence map›Paper›PMID 20589293›Full record

ArticleChemical communications (Cambridge, England)2010

Nitrogen-bound diazeniumdiolated amidines.

Debanjan Biswas, Jeffrey R Deschamps, Larry K Keefer, Joseph A Hrabie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Debanjan BiswasChemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. biswasd@mail.nih.gov
Jeffrey R Deschamps
Larry K Keefer
Joseph A Hrabie
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USUnited States Naval Research Laboratory · US

Funding

Using Diazeniumdiolate Chemistry to Design Nitric Oxide-Based TherapiesZIABC005673 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEEFER, LARRY K · 2009 to 2015
$5.5M
Diazeniumdiolates as Broad-Spectrum Anticancer AgentsZIABC011188 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEEFER, LARRY K · 2009 to 2015
$5.2M
Using Diazeniumdiolate Chemistry to Design Nitric Oxide-Based TherapiesZ01BC005673 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEEFER, LARRY K · 1996 to 2008
$2.9M
SIGMA2 RECEPTOR REGULATION OF THE DOPAMINE TRANSPORTERF31DA006002 · NIDA · GEORGE WASHINGTON UNIVERSITY · PI DERBEZ, ALICIA E · 1999 to 2003
$110k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 BC005673Intramural NIH HHS ZIA BC005673Intramural NIH HHS ZIA BC011188NCI NIH HHS HHSN261200800001ENIDA NIH HHS Y01 DA006002NIDA NIH HHS Y1-DA6002
6 · The paper itself

Abstract

In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.

Indexed as

AmidinesAzo CompoundsMolecular ConformationNitric OxideNitrogenProdrugsAmidinesAzo CompoundsdiazeniumdiolateNitric OxideNitrogenProdrugs

Identifiers

PMID20589293
PMCPMC6959519
OpenAlexW2047504478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.