ArticleFrontiers in aging neuroscience2010
Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism: Evidence from a Population-Based Study.
Article in Frontiers in aging neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Pooled it
- The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults.Scientific reports · 2021Trial
- Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.Cellular and molecular neurobiology · 2026Review
- Normative Data for the 12-Item Sniffin' Sticks Odor Identification Test in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Associations between olfactory dysfunction and cognition: a scoping review.Journal of neurology · 2024Article
- The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration.Journal of personalized medicine · 2023Review
- Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.Scientific reports · 2022Article
- The Olfactory System as Marker of Neurodegeneration in Aging, Neurological and Neuropsychiatric Disorders.International journal of environmental research and public health · 2021Review
- Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- A Prospective Study on Risk Factors for Olfactory Dysfunction in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management.Frontiers in aging neuroscience · 2020Review
- Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.Behavior genetics · 2020Article
- Mechanisms Linking Olfactory Impairment and Risk of Mortality.Frontiers in neuroscience · 2020Review
- Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Phantom Smells: Prevalence and Correlates in a Population-Based Sample of Older Adults.Chemical senses · 2017Article
- The Rate of Age-Related Olfactory Decline Among the General Population of Older U.S. Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- The influences of age on olfaction: a review.Frontiers in psychology · 2014Review
- Article
- Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability in young adults.Journal of biomedical science · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70-90 years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45-65 years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.