ArticleFrontiers in behavioral neuroscience2010
What roles do tonic inhibition and disinhibition play in the control of motor programs?
Article in Frontiers in behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors.International journal of molecular sciences · 2024Review
- Article
- Inhibition for gain modulation in the motor system.Experimental brain research · 2022Review
- Interneuronal mechanisms for learning-induced switch in a sensory response that anticipates changes in behavioral outcomes.Current biology : CB · 2021Article
- Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- A disinhibitory mechanism biases Drosophila innate light preference.Nature communications · 2019Article
- Generalized Unsafety Theory of Stress: Unsafe Environments and Conditions, and the Default Stress Response.International journal of environmental research and public health · 2018Review
- Voluntary movement reverses the effect of cathodal transcranial direct current stimulation (tDCS) on corticomotor excitability.Experimental brain research · 2017Article
- Article
- An Investigation of the Dynamical Transitions in Harmonically Driven Random Networks of Firing-Rate Neurons.Cognitive computation · 2017Article
- Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice.Current biology : CB · 2014Article
- Cortical activity in the null space: permitting preparation without movement.Nature neuroscience · 2014Article
- The roles of monkey M1 neuron classes in movement preparation and execution.Journal of neurophysiology · 2013Article
- Distributed network organization underlying feeding behavior in the mollusk Lymnaea.Neural systems & circuits · 2012Article
- Proactive inhibitory control of response as the default state of executive control.Frontiers in psychology · 2012Article
- Reproduction-related sound production of grasshoppers regulated by internal state and actual sensory environment.Frontiers in neuroscience · 2012Article
- Article
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Abstract
Animals show periods of quiescence interspersed with periods of motor activity. In a number of invertebrate and vertebrate systems, quiescence is achieved by active suppression of motor behavior is due to tonic inhibition induced by sensory input or changes in internal state. Removal of this inhibition (disinhibition) has the converse effect tending to increase the level of motor activity. We show that tonic inhibition and disinhibition can have a variety of roles. It can simply switch off specific unwanted motor behaviors, or modulate the occurrence of a motor response, a type of 'threshold' controlling function, or be involved in the selection of a particular motor program by inhibiting 'competing' motor mechanisms that would otherwise interfere with the carrying out of a desired movement. A suggested general function for tonic inhibition is to prevent unnecessary non-goal directed motor activity that would be energetically expensive. The reason why basic motor programs might be a particular target for tonic inhibition is that many of them involve central pattern generator circuits that are often spontaneously active and need to be actively suppressed for energy saving. Based on this hypothesis, tonic inhibition represents the default state for energy saving and motor programs are switched-on when required by removal of this inhibition.
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