Evidence map›Paper›PMID 20588552›Full record

ArticleOptics express2010

Dynamic spectral-domain optical coherence elastography for tissue characterization.

Xing Liang, Steven G Adie, Renu John, Stephen A Boppart

Abstract read
In one paragraph

Article in Optics express, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  2. Article
  3. Article
  4. A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review of optical coherence tomography in oncology.Journal of biomedical optics · 2017
    Review
  12. Optical coherence elastography in ophthalmology.Journal of biomedical optics · 2017
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xing LiangDepartment of Electrical and Computer Engineering, Urbana, IL 61801, USA.
Steven G Adie
Renu John
Stephen A Boppart

Funding

Targeted Microspheres for Contrast Enhancement in Optical Coherence TomographyR01EB009073 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A · 2009 to 2012
$1.3M
Optical Coherence Tomography Image-Guided Surgical Resection of Solid TumorsR01EB005221 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A · 2006 to 2009
$1.3M
Investigating Tumor Growth Dynamics Using Multimodal Contrast Agents and OpticalRC1CA147096 · NCI · PURDUE UNIVERSITY · PI WEI, ALEXANDER · 2009 to 2010
$999k
NCI NIH HHS RC1 CA147096NIBIB NIH HHS R01 EB005221NIBIB NIH HHS R01 EB009073
6 · The paper itself

Abstract

A dynamic spectral-domain optical coherence elastography (OCE) imaging technique is reported. In this technique, audio-frequency compressive vibrations are generated by a piezoelectric stack as external excitation, and strain rates in the sample are calculated and mapped quantitatively using phase-sensitive spectral-domain optical coherence tomography. At different driving frequencies, this technique provides contrast between sample regions with different mechanical properties, and thus is used to mechanically characterize tissue. We present images of a three-layer silicone tissue phantom and rat tumor tissue ex vivo, based on quantitative strain rate. Both acquisition speed and processing speed are improved dramatically compared with previous OCE imaging techniques. With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications.

Indexed as

AnimalsBiomarkers, TumorElasticity Imaging TechniquesEquipment DesignFemaleMammary Neoplasms, AnimalMethylnitrosoureaModels, TheoreticalPhantoms, ImagingRatsRats, Inbred WFScattering, RadiationSiliconesTomography, Optical CoherenceBiomarkers, TumorMethylnitrosoureaSilicones

Identifiers

PMID20588552
PMCPMC3310369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.