Evidence map›Paper›PMID 20588320›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2010

Gabapentin suppresses cortical spreading depression susceptibility.

Ulrike Hoffmann, Ergin Dileköz, Chiho Kudo, Cenk Ayata

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 41 citations in OpenAlex.

  1. Gabapentin and cognitive impairment after traumatic brain injury: A multinational cohort of 49,925 patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pregabalin as a Pain Therapeutic: Beyond Calcium Channels.Frontiers in cellular neuroscience · 2020
    Review
  11. Current Status of Antiepileptic Drugs as Preventive Migraine Therapy.Current treatment options in neurology · 2019
    Review
  12. In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  13. Review
  14. P/Q-type calcium channel modulators.British journal of pharmacology · 2012
    Review
  15. Pharmacological targeting of spreading depression in migraine.Expert review of neurotherapeutics · 2012
    Review
  16. Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ulrike HoffmannDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Ergin Dileköz
Chiho Kudo
Cenk Ayata
Harvard University · USMassachusetts General Hospital · US

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Neural & Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine ModelsR01NS061505 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK · 2008 to 2012
$1.8M
NINDS NIH HHS NS055104NINDS NIH HHS NS061505NINDS NIH HHS R01 NS061505
6 · The paper itself

Abstract

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury.

Indexed as

AminesAnesthesiaAnimalsCalcium Channel BlockersCalcium Channels, N-TypeCortical Spreading DepressionCyclohexanecarboxylic AcidsElectroencephalographyElectrophysiologyExcitatory Amino Acid AntagonistsGabapentingamma-Aminobutyric AcidGlutamic AcidInjections, IntravenousMalePotassium ChlorideAminesCalcium Channel BlockersCalcium Channels, N-TypeCyclohexanecarboxylic AcidsExcitatory Amino Acid AntagonistsGabapentingamma-Aminobutyric AcidGlutamic AcidPotassium Chloride

Identifiers

PMID20588320
PMCPMC2949257
OpenAlexW2017444876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.