ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
PET scan perfusion imaging in the Prader-Willi syndrome: new insights into the psychiatric and social disturbances.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients.Orphanet journal of rare diseases · 2011Trial
- Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader-Willi syndrome.The Journal of physiology · 2026Article
- Early neurodevelopmental brain perfusion abnormalities and functional connectivity findings in infants with Prader-Willi syndrome.Journal of neurodevelopmental disorders · 2026Article
- Aberrant local and global neural activation patterns in pediatric Prader-Willi syndrome.Frontiers in neuroscience · 2026Article
- Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory.Clinical epigenetics · 2021Article
- Cerebellar Dysfunction in Adults with Prader Willi Syndrome.Journal of clinical medicine · 2021Article
- The RDoC approach for translational psychiatry: Could a genetic disorder with psychiatric symptoms help fill the matrix? the example of Prader-Willi syndrome.Translational psychiatry · 2020Review
- A study of voice and non-voice processing in Prader-Willi syndrome.Orphanet journal of rare diseases · 2020Article
- Face processing and exploration of social signals in Prader-Willi syndrome: a genetic signature.Orphanet journal of rare diseases · 2019Article
- Grey matter volume and cortical structure in Prader-Willi syndrome compared to typically developing young adults.NeuroImage. Clinical · 2018Article
- Brain structural alterations in obese children with and without Prader-Willi Syndrome.Human brain mapping · 2017Article
- Anomalous basal ganglia connectivity and obsessive-compulsive behaviour in patients with Prader Willi syndrome.Journal of psychiatry & neuroscience : JPN · 2016Article
- Puzzle Pieces: Neural Structure and Function in Prader-Willi Syndrome.Diseases (Basel, Switzerland) · 2015Review
- Learning by observation and learning by doing in Prader-Willi syndrome.Journal of neurodevelopmental disorders · 2015Article
- Obesity: pathophysiology and intervention.Nutrients · 2014 · on this mapReview
- Altered functional brain networks in Prader-Willi syndrome.NMR in biomedicine · 2013Article
- The neuroanatomy of genetic subtype differences in Prader-Willi syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Prader-Willi syndrome: A primer for clinicians.International journal of pediatric endocrinology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Prader-Willi syndrome (PWS), a rare multisystem genetic disease, leads to severe disabilities, such as morbid obesity, endocrine dysfunctions, psychiatric disorders, and social disturbances. We explored the whole brain of patients with PWS to detect abnormalities that might explain the behavioral and social disturbances, as well as the psychiatric disorders of these patients. Nine patients with PWS (six males, three females; mean age 16.4 years) underwent a positron emission tomography (PET) scan with H(2)(15)O as a tracer to measure regional cerebral blood flow (rCBF). The images were compared with those acquired from nine controls (six males, three females; mean age 21.2 years). A morphologic magnetic resonance imaging (MRI) was also performed in PWS patients, and their cognitive and behavioral skills were assessed with Wechsler Intelligence Scale for Children III and the Child Behavior Check List (CBCL). The MRI images showed no evident anatomic abnormalities, whereas PET scans revealed hypoperfused brain regions in PWS patients compared with controls, particularly in the anterior cingulum and superior temporal regions. We observed a significant relationship (P<0.05) between rCBF in the hypoperfused regions and CBCL scores. The functional consequences of these perfusion abnormalities in specific brain regions might explain the behavioral and social problems observed in these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.