Evidence map›Paper›PMID 20587727›Full record

SynthesisDiabetes care2010

A1C level and future risk of diabetes: a systematic review.

Xuanping Zhang, Edward W Gregg, David F Williamson, Lawrence E Barker, William Thomas, Kai McKeever Bullard, Giuseppina Imperatore, Desmond E Williams, Ann L Albright

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 10 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 10 syntheses or guidelines pooled it, 418 citations in OpenAlex.

  1. Lower-Intensity Interventions for Prediabetes: A Systematic Review.American journal of preventive medicine · 2023
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  9. Guideline
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  11. Using Peer Support to Prevent Diabetes: Results of a Pragmatic RCT.American journal of preventive medicine · 2023
    Trial
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  19. Review
  20. Prediabetes in children and adolescents: what do we need to know?Annals of pediatric endocrinology & metabolism · 2026
    Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xuanping ZhangDivision of Diabetes Translation, National Center for Chronic Disease Prevention and HealthPromotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Xuanping Zhang, xbz2@cdc.gov
Edward W Gregg
David F Williamson
Lawrence E Barker
William Thomas
Kai McKeever Bullard
Giuseppina Imperatore
Desmond E Williams
Ann L Albright
Centers for Disease Control and Prevention · USNational Center for Chronic Disease Prevention and Health Promotion · USEmory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined ranges of A1C useful for identifying persons at high risk for diabetes prior to preventive intervention by conducting a systematic review. From 16 included studies, we found that annualized diabetes incidence ranged from 0.1% at A1C <5.0% to 54.1% at A1C >or=6.1%. Findings from 7 studies that examined incident diabetes across a broad range of A1C categories showed 1) risk of incident diabetes increased steeply with A1C across the range of 5.0 to 6.5%; 2) the A1C range of 6.0 to 6.5% was associated with a highly increased risk of incident diabetes, 25 to 50% incidence over 5 years; 3) the A1C range of 5.5 to 6.0% was associated with a moderately increased relative risk, 9 to 25% incidence over 5 years; and 4) the A1C range of 5.0 to 5.5% was associated with an increased incidence relative to those with A1C <5%, but the absolute incidence of diabetes was less than 9% over 5 years. Our systematic review demonstrated that A1C values between 5.5 and 6.5% were associated with a substantially increased risk for developing diabetes.

Indexed as

Diabetes Mellitus, Type 2Glycated HemoglobinHumansIncidenceRisk FactorsGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID20587727
PMCPMC2890379
OpenAlexW2137837290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.