Evidence map›Paper›PMID 20587689›Full record

ArticleVeterinary pathology2010

Pathbase and the MPATH ontology. Community resources for mouse histopathology.

P N Schofield, M Gruenberger, J P Sundberg

Open access · greenAbstract read
In one paragraph

Article in Veterinary pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. The Mouse Models of Human Cancer database (MMHCdb).Disease models & mechanisms · 2023
    Article
  3. Spontaneous and Induced Animal Models for Cancer Research.Diagnostics (Basel, Switzerland) · 2020
    Review
  4. PATHBIO: an international training program for precision mouse phenotyping.Mammalian genome : official journal of the International Mammalian Genome Society · 2020
    Article
  5. Article
  6. Toward a standard ontology of surgical process models.International journal of computer assisted radiology and surgery · 2018
    Article
  7. Article
  8. Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2016
    Article
  9. Review
  10. The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
    Article
  11. Article
  12. Genetic determinants of fibro-osseous lesions in aged inbred mice.Experimental and molecular pathology · 2016
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Chapter 15: disease gene prioritization.PLoS computational biology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

P N SchofieldThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
M Gruenberger
J P Sundberg
Jackson Laboratory · USUniversity of Cambridge · GB

Funding

Translational CoreP30AG038070 · NIA · JACKSON LABORATORY · PI John Matthew Mahoney · 2010 to 2026
$19.3M
Mouse Models of Human Cancer DatabaseR01CA089713 · NCI · JACKSON LABORATORY · PI BULT, CAROL J · 2002 to 2025
$17.5M
Cpdm: Cloning a Gene That Regulates Eosinophil FunctionR01AR049288 · NIAMS · JACKSON LABORATORY · PI BOWCOCK, ANNE MARY, HOGENESCH, HARM · 2004 to 2016
$5.9M
Pathology of Mouse Models of Human DiseaseR13OD010920 · OD · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2012 to 2021
$200k
PATHOLOGY OF THE LABORATORY MOUSEU13RR017436 · NCRR · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2002 to 2006
$130k
Pathology of the Laboratory MouseR13RR017436 · NCRR · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2007 to 2011
$100k
NCI NIH HHS CA089713NCI NIH HHS R01 CA089713NCRR NIH HHS R13 RR017436NCRR NIH HHS RR17436NCRR NIH HHS U13 RR017436NIAMS NIH HHS AR49288NIAMS NIH HHS R01 AR049288NIA NIH HHS P30 AG038070NIH HHS R13 OD010920
6 · The paper itself

Abstract

Pathbase, the database of mouse histopathology images, was developed as a resource to provide free access to representative images of lesions in background and mutant strains of laboratory mice. When utilized with diagnostic workups or phenotyping of mutant mice, it can provide a "virtual second opinion" for those working without access to groups of experienced pathologists. This is a community resource, and it facilitates the sharing of expertise and data among members of the pathology community worldwide. MPATH-the mouse pathology ontology-was developed alongside Pathbase for the annotation of images and now represents an important resource for the coding of diagnoses, permitting sophisticated data retrieval and computational analysis of mouse phenotypes. In this article, the structure and use of MPATH is discussed, along with current and future challenges for the coding of mutant mouse phenotypes.

Indexed as

Databases, FactualPathologyAnimalsMiceMice, Mutant StrainsPhenotype

Identifiers

PMID20587689
PMCPMC3038412
OpenAlexW2138443244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.