ArticleGut2010
In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.
Article in Gut, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Gut homeostasis, injury, and healing: New therapeutic targets.World journal of gastroenterology · 2022Review
- Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives.International journal of molecular sciences · 2021Review
- Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract.ACS pharmacology & translational science · 2020Review
- Multiple calcium sources are required for intracellular calcium mobilization during gastric organoid epithelial repair.Physiological reports · 2020Article
- Extracting Insights From Temporal Data by Integrating Dynamic Modeling and Machine Learning.Frontiers in physiology · 2020Article
- Effect of Tff3 Deficiency and ER Stress in the Liver.International journal of molecular sciences · 2019Article
- Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps.Nature communications · 2019Article
- Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids.The Journal of physiology · 2019Article
- Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal PathogenInfection and immunity · 2019Article
- Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma.Biomedical reports · 2019Article
- Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair.Annual review of physiology · 2019Review
- Cell injury triggers actin polymerization to initiate epithelial restitution.Journal of cell science · 2018Article
- CaOncotarget · 2017Review
- Trefoil Factor Peptides and Gastrointestinal Function.Annual review of physiology · 2017Review
- Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations.Cellular and molecular gastroenterology and hepatology · 2016Article
- IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection.Cellular and molecular gastroenterology and hepatology · 2015Article
- Importance of Ca(2+) in gastric epithelial restitution-new views revealed by real-time in vivo measurements.Current opinion in pharmacology · 2014Review
- Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori.PLoS pathogens · 2014Article
- In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.The Journal of biological chemistry · 2013Article
- Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTrefoil factor (TFF) peptides are expressed in gastric tissues, where they are part of the epithelial defences. To complement previous in vitro work, the goal of the present study was to examine directly if TFF2 was essential for gastric restitution in vivo during the recovery from microscopic damage.
designTFF2 mutant (KO) mice were examined to study the epithelial repair process in vivo after laser-induced photodamage (LPD). Using two-photon laser energy absorption (710 nm), LPD was imposed on an approximately 3-5 cell region of surface epithelium in anaesthetised mouse stomach. Responses to damage were evaluated during confocal time-lapse microscopy; including area of damage and the extracellular pH adjacent to the damaged surface (Cl-NERF pH sensor).
resultsIn control (TFF2+/+ and TFF2+/-) mice, damaged cells were exfoliated and the damaged epithelium was repaired by indomethacin. The resting surface pH was similar between control and TFF2-KO animals, but the post-LPD alkalisation of surface pH observed in control mice (pH 0.3 + or - 0.05, n=21) was attenuated in the TFF2-KO stomach (pH -0.08 + or - 0.09, n=18). Recobinant rat TFF3 partially rescued the attenuated surface pH change in TFF2-KO stomach, in the presence or absence of indomethacin.
conclusionsIn the gastric epithelium in vivo, TFFs promote epithelial restitution via a mechanism that does not require cyclooxygenase activation. A novel role for TFFs to affect gastric surface pH is observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.