ArticleCancer research2010
MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.
Article in Cancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Review
- MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure.International journal of radiation oncology, biology, physics · 2019Article
- Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination.Cancer research · 2019Article
- Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress.Cancer research · 2019Article
- Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- MicroRNA signatures and Foxp3Oncotarget · 2018Article
- The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.Gynecologic oncology · 2017Review
- New roles for Dicer in the nucleolus and its relevance to cancer.Cell cycle (Georgetown, Tex.) · 2017Review
- BCL-W has a fundamental role in B cell survival and lymphomagenesis.The Journal of clinical investigation · 2017Article
- DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.Oncotarget · 2016Article
- Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.Nucleic acids research · 2016Article
- DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.Journal of cell science · 2016Article
- miR-31 and miR-17-5p levels change during transformation of follicular lymphoma.Human pathology · 2016Article
- Article
- MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential.Current genomics · 2015Article
- Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.PloS one · 2015Article
- Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.Medical oncology (Northwood, London, England) · 2014Article
- Reproducible combinatorial regulatory networks elucidate novel oncogenic microRNAs in non-small cell lung cancer.RNA (New York, N.Y.) · 2014Article
- Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.Cancer research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Many tumor cells express globally reduced levels of microRNAs (miRNA), suggesting that decreased miRNA expression in premalignant cells contributes to their tumorigenic phenotype. In support of this, Dicer, an RNase III-like enzyme that controls the maturation of miRNA, was recently shown to function as a haploinsufficient tumor suppressor in nonhematopoietic cells. Because the Myc oncoprotein, a critical inducer of B-cell lymphomas, was reported to suppress the expression of multiple miRNAs in lymphoma cells, it was presumed that a deficiency of Dicer and subsequent loss of miRNA maturation would accelerate Myc-induced lymphoma development. We report here that, surprisingly, a haploinsufficiency of Dicer in B cells failed to promote B-cell malignancy or accelerate Myc-induced B-cell lymphomagenesis in mice. Moreover, deletion of Dicer in B cells of CD19-cre(+)/Emicro-myc mice significantly inhibited lymphomagenesis, and all lymphomas that did arise in these mice lacked functional Cre expression and retained at least one functional Dicer allele. Uncharacteristically, the lymphomas that frequently developed in the CD19-cre(+)/Dicer(fl/fl)/Emicro-myc mice were of very early precursor B-cell origin, a stage of B-cell development prior to Cre expression. Therefore, loss of Dicer function was not advantageous for lymphomagenesis, but rather, Dicer ablation was strongly selected against during Myc-induced B-cell lymphoma development. Moreover, deletion of Dicer in established B-cell lymphomas resulted in apoptosis, revealing that Dicer is required for B-cell lymphoma survival. Thus, Dicer does not function as a haploinsufficient tumor suppressor in B cells and is required for B-cell lymphoma development and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.