ArticleGenome medicine2010
Genomic insights into early-onset obesity.
Article in Genome medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- The transition from preclinical to clinical obesity: the importance of a borderline stage.Clinical science (London, England : 1979) · 2026Review
- Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity.Endocrine connections · 2025Article
- Article
- Are single-nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese-asthma in children?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Review
- Article
- Childhood obesity from the genes to the epigenome.Frontiers in endocrinology · 2024Review
- A comprehensive review of genetic causes of obesity.World journal of pediatrics : WJP · 2024Review
- Cardiovascular Risk in Pediatrics: A Dynamic Process during the First 1000 Days of Life.Pediatric reports · 2023Review
- Association between the age at onset of overweight and obesity and the subsequent risk of hypertension in Chinese adults.BMC cardiovascular disorders · 2023Article
- Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years).Journal of cachexia, sarcopenia and muscle · 2023Article
- Does Childhood Obesity Trigger Neuroinflammation?Biomedicines · 2022Article
- Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.eLife · 2022Article
- The Effects of COVID-19 on the Eating Habits of Children and Adolescents in Italy: A Pilot Survey Study.Nutrients · 2021Article
- A Streamlined Approach to Prader-Willi and Angelman Syndrome Molecular Diagnostics.Frontiers in genetics · 2021Article
- Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.Current cardiology reports · 2020Review
- Covid-19 Confinement and Changes of Adolescent's Dietary Trends in Italy, Spain, Chile, Colombia and Brazil.Nutrients · 2020Article
- Effects of Bariatric Surgery in Early- and Adult-Onset Obesity in the Prospective Controlled Swedish Obese Subjects Study.Diabetes care · 2020Article
- Whole exome sequencing reveals novel LEPR frameshift mutation in severely obese children from Western India.Molecular genetics & genomic medicine · 2019Article
- Obesity and the Mediterranean Diet: A Review of Evidence of the Role and Sustainability of the Mediterranean Diet.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological causes of childhood obesity are complex. Environmental factors, such as massive marketing campaigns for food leading to over-nutrition and snacking and the decline in physical activity, have undoubtedly contributed to the increased prevalence of overweight and obesity in children, but these cannot be considered as the only causes. Susceptibility to obesity is also determined to a great extent by genetic factors. Furthermore, molecular mechanisms involved in the regulation of gene expression, such as epigenetic mechanisms, can increase the risk of developing early-onset obesity. There is evidence that early-onset obesity is a heritable disorder, and a range of genetic factors have recently been shown to cause monogenic, syndromic and polygenic forms of obesity, in some cases interacting with environmental exposures. Modifications of the transcriptome can lead to increased adiposity, and the gut microbiome has recently been shown to be key to the genesis of obesity. These new genomic discoveries complement previous knowledge on the development of early-onset obesity and provide new perspectives for research on the complex molecular and physiological mechanisms involved in this disease. Personalized preventive strategies and genomic medicine may become possible in the near future.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.