ArticleBiology direct2010
Mitochondrial DNA, chloroplast DNA and the origins of development in eukaryotic organisms.
Article in Biology direct, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
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- The biological and evolutionary consequences of competition between DNA sequences that benefit the cell and DNA sequences that benefit themselves.Nucleic acids research · 2025Review
- Chlomito: a novel tool for precise elimination of organelle genome contamination from nuclear genome assembly.Frontiers in plant science · 2024Article
- Article
- Oxidative and Glycation Damage to Mitochondrial DNA and Plastid DNA during Plant Development.Antioxidants (Basel, Switzerland) · 2023Review
- Complete mitochondrial genomes of three Mangifera species, their genomic structure and gene transfer from chloroplast genomes.BMC genomics · 2022Article
- Glycation damage to organelles and their DNA increases during maize seedling development.Scientific reports · 2022Article
- Review
- Cell-Inspired All-Aqueous Microfluidics: From Intracellular Liquid-Liquid Phase Separation toward Advanced Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- The Photosynthetic Adventure of Paulinella Spp.Results and problems in cell differentiation · 2020Article
- Reactive Oxygen Species, Antioxidant Agents, and DNA Damage in Developing Maize Mitochondria and Plastids.Frontiers in plant science · 2020Article
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Darwinism for the Genomic Age: Connecting Mutation to Diversification.Frontiers in genetics · 2017Article
- Selection for Mitochondrial Quality Drives Evolution of the Germline.PLoS biology · 2016Article
- DNA maintenance in plastids and mitochondria of plants.Frontiers in plant science · 2015Review
- Changes in DNA damage, molecular integrity, and copy number for plastid DNA and mitochondrial DNA during maize development.Journal of experimental botany · 2014Article
- Aging: A mitochondrial DNA perspective, critical analysis and an update.World journal of experimental medicine · 2014Review
- Geometry shapes evolution of early multicellularity.PLoS computational biology · 2014Article
- The evolutionary origin of somatic cells under the dirty work hypothesis.PLoS biology · 2014Article
- DNA abandonment and the mechanisms of uniparental inheritance of mitochondria and chloroplasts.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral proposals have been made to explain the rise of multicellular life forms. An internal environment can be created and controlled, germ cells can be protected in novel structures, and increased organismal size allows a "division of labor" among cell types. These proposals describe advantages of multicellular versus unicellular organisms at levels of organization at or above the individual cell. I focus on a subsequent phase of evolution, when multicellular organisms initiated the process of development that later became the more complex embryonic development found in animals and plants. The advantage here is realized at the level of the mitochondrion and chloroplast. HYPOTHESIS: The extreme instability of DNA in mitochondria and chloroplasts has not been widely appreciated even though it was first reported four decades ago. Here, I show that the evolutionary success of multicellular animals and plants can be traced to the protection of organellar DNA. Three stages are envisioned. Sequestration allowed mitochondria and chloroplasts to be placed in "quiet" germ line cells so that their DNA is not exposed to the oxidative stress produced by these organelles in "active" somatic cells. This advantage then provided Opportunity, a period of time during which novel processes arose for signaling within and between cells and (in animals) for cell-cell recognition molecules to evolve. Development then led to the enormous diversity of animals and plants. IMPLICATIONS: The potency of a somatic stem cell is its potential to generate cell types other than itself, and this is a systems property. One of the biochemical properties required for stemness to emerge from a population of cells might be the metabolic quiescence that protects organellar DNA from oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.