ArticleBMC geriatrics2010
Hertfordshire sarcopenia study: design and methods.
Article in BMC geriatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.GeroScience · 2026Article
- The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways.Journal of cachexia, sarcopenia and muscle · 2024Review
- Trigonelline is an NADNature metabolism · 2024Article
- The serum small non-coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Prevalence and factors associated with sarcopenia among older adults in a post-acute hospital in Singapore.PloS one · 2024Article
- Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2023Article
- Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function.Epigenetics · 2022Article
- Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).Journal of cachexia, sarcopenia and muscle · 2022Article
- Mitochondrial oxidative capacity and NADNature communications · 2019Article
- The Hertfordshire Cohort Study: an overview.F1000Research · 2019Review
- Associations Between Objectively Measured Physical Activity, Body Composition and Sarcopenia: Findings from the Hertfordshire Sarcopenia Study (HSS).Calcified tissue international · 2018Article
- Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS).Calcified tissue international · 2018Article
- Learning from older peoples' reasons for participating in demanding, intensive epidemiological studies: a qualitative study.BMC medical research methodology · 2017Article
- Sarcopenia and frailty: new challenges for clinical practice.Clinical medicine (London, England) · 2016Article
- Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.Aging cell · 2016Review
- Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome.Journal of visualized experiments : JoVE · 2016Article
- Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).BMC geriatrics · 2015Article
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- Mortality as an adverse outcome of sarcopenia.The journal of nutrition, health & aging · 2013Article
- Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle.International journal of molecular medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSarcopenia is defined as the loss of muscle mass and strength with age. Although a number of adult influences are recognised, there remains considerable unexplained variation in muscle mass and strength between older individuals. This has focused attention on influences operating earlier in life. Our objective for this study was to identify life course influences on muscle mass and strength in an established birth cohort and develop methodology for collection of muscle tissue suitable to investigate underlying cellular and molecular mechanisms.
methodsOne hundred and five men from the Hertfordshire Cohort Study (HCS), born between 1931 and 1939 who have historical records of birth weight and weight at one year took part in the Hertfordshire Sarcopenia Study (HSS). Each participant consented for detailed characterisation of muscle mass, muscle function and aerobic capacity. In addition, a muscle biopsy of the vastus lateralis using a Weil-Blakesley conchotome was performed. Data on muscle mass, function and aerobic capacity was collected on all 105 participants. Muscle biopsy was successfully carried out in 102 participants with high rates of acceptability. No adverse incidents occurred during the study. DISCUSSION: The novel approach of combining epidemiological and basic science characterisation of muscle in a well established birth cohort will allow the investigation of cellular and molecular mechanisms underlying life course influences on sarcopenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.