Trial reportActa paediatrica (Oslo, Norway : 1992)2010
Early predictors of hypertension in prematurely born adolescents.
Trial report in Acta paediatrica (Oslo, Norway : 1992), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of preterm birth and later systolic blood pressure.Hypertension (Dallas, Tex. : 1979) · 2012Pooled it
- Continuous versus intermittent bolus infusion of calcium in preterm infants receiving total parenteral nutrition: a randomized blind clinical trial.BMC pediatrics · 2024Trial
- Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.The Journal of pediatrics · 2018Trial
- Cardio-metabolic risks in preterm children: opportunities, cautions and the importance of longer-term study.Pediatric research · 2026Review
- Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies.International journal of molecular sciences · 2025Review
- Secondary Hypertension in Children-Identifying and Investigating at Risk Children.Current hypertension reports · 2025Review
- The critical importance of follow-up to school age: Contributions of the NICHD Neonatal Research Network.Seminars in perinatology · 2022Article
- Article
- Very preterm birth results in later lower platelet activation markers.Pediatric research · 2021Observational
- Adrenal Steroid Metabolism and Blood Pressure in 5- to 7-Year-Old Children Born Preterm as Compared to Peers Born at Term.Frontiers in pediatrics · 2021Article
- Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls.Children (Basel, Switzerland) · 2020Article
- Integration of an interpretable machine learning algorithm to identify early life risk factors of childhood obesity among preterm infants: a prospective birth cohort.BMC medicine · 2020Article
- Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm.Pediatric research · 2019Article
- The association of gestational age and birth weight with blood pressure among children: a Chinese national study.Journal of human hypertension · 2018Article
- High Blood Pressure at Early School Age Among Extreme Preterms.Pediatrics · 2018Article
- Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN].Pediatric research · 2018Article
- Cardiac Disease after Pregnancy: A Growing Problem.European cardiology · 2017Review
- Association among prematurity (<30 weeks' gestational age), blood pressure, urinary albumin, calcium, and phosphate in early childhood.Pediatric nephrology (Berlin, Germany) · 2017Observational
- Article
- Long-term metabolic risk among children born premature or small for gestational age.Nature reviews. Endocrinology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo assess the blood pressure of former preterm and term matched adolescent controls and to identify risk factors associated with blood pressure at 16 years.
designObservational cohort study. Secondary analysis of a randomized clinical trial.
settingThree academic centres participating in the Multicenter Indomethacin IVH Prevention Trial.
participantsA total of 296 children born in 1989-1992 with birth weights 600 to <1250 g who participated in the Multicenter Indomethacin IVH Prevention Trial and 95 term controls were evaluated at 16 years.
main outcome measuresBlood pressure and predictors of blood pressure.
resultsThe adjusted mean difference in blood pressure for preterm adolescents was 5.1 mm Hg; p=0.002 for systolic and 2.1 mm Hg; p=0.027 for diastolic blood pressure. Among preterms, the primary predictors of increased systolic blood pressure were weight gain velocity between birth and 36 months (b=8.54, p<0.001), pre-eclampsia (b=5.67, p=0.020), non-white race (b=3.77, p=0.04) and male gender (b=5.09). Predictors of diastolic blood pressure were weight gain velocity between birth and 36 months (b=4.69, p=0.001), brain injury (b=6.51, p=0.002) and male gender (b=-2.4, p=0.02).
conclusionsEarly programming secondary to increased early weight gain velocity, intrauterine stress and neonatal brain injury may all contribute to risk of increased blood pressure among former preterm adolescents.
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Registered trials
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