ArticleAlcoholism, clinical and experimental research2010
Ethanol enhances taurine-activated glycine receptor function.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- An emerging role for synaptic ZnPharmacology & therapeutics · 2026Review
- Taurine Suppression of Central Amygdala GABAergic Inhibitory Signaling via Glycine Receptors Is Disrupted in Alcohol Dependence.Alcoholism, clinical and experimental research · 2020Article
- Allosteric modulation of the glycine receptor activated by agonists differing in efficacy.Brain research · 2015Article
- Trifluoroacetate is an allosteric modulator with selective actions at the glycine receptor.Neuropharmacology · 2012Article
- Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems.Recent patents on CNS drug discovery · 2012Article
- Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor.The Journal of pharmacology and experimental therapeutics · 2012Article
- Acamprosate reduces ethanol drinking behaviors and alters the metabolite profile in mice lacking ENT1.Neuroscience letters · 2011Article
- Role of taurine on acid secretion in the rat stomach.Journal of biomedical science · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEmerging evidence suggests that taurine acts as a partial agonist on glycine receptors (GlyR) in vitro and in vivo. Ethanol acts as an allosteric modulator on the GlyR producing a leftward shift of the glycine concentration-response curve, with no enhancing effects observed at saturating glycine concentrations. However, to date, no electrophysiological studies have been performed on ethanol modulation of taurine-activated GlyR.
methodsWild-type alpha1 GlyR, or those bearing a serine-267 to isoleucine replacement (S267I), were homomerically expressed in Xenopus oocytes and voltage clamped at -70 mV. Ethanol was co-applied with varying concentrations of glycine or taurine and the enhancing effects of ethanol compared.
resultsEthanol potentiated glycine- and taurine-activated GlyR responses in a concentration-dependent manner. It shifted taurine and glycine concentration-response curves to the left, having no effects at saturating agonist concentrations. Chelation of zinc by tricine decreased ethanol enhancement of taurine-gated GlyR function. The S267I mutation prevented ethanol enhancement of taurine-mediated responses as previously also reported for glycine.
conclusionEthanol modulates taurine activation of GlyR function by a mechanism similar to that of the full agonist glycine. The lack of effect of ethanol at saturating taurine concentrations provides mechanistic information on alcohol actions at the GlyR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.