Evidence map›Paper›PMID 20586639›Full record

ArticleArchives of pathology & laboratory medicine2010

Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization.

Joanna J Phillips, Anjan Misra, Burt G Feuerstein, Sandeep Kunwar, Tarik Tihan

Abstract readCase Reports
In one paragraph

Article in Archives of pathology & laboratory medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Primary tumors of the posterior pituitary: A systematic review.Reviews in endocrine & metabolic disorders · 2019
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
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  9. Review
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  12. Clinical features, diagnosis and therapy of pituicytoma: an update.Journal of endocrinological investigation · 2019
    Review
  13. Article
  14. Pituicytoma-An outlook on possible targeted therapies.CNS neuroscience & therapeutics · 2017
    Article
  15. Article
  16. Article
  17. Review
  18. Second-stage transsphenoidal approach (TSA) for highly vascular pituicytomas in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joanna J PhillipsNeuropathology Unit, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0102, USA. joanna.phillips@ucsf.edu
Anjan Misra
Burt G Feuerstein
Sandeep Kunwar
Tarik Tihan

Funding

SIGNIFICANCE OF CHROMOSOME 7 ALTERATIONS IN GLIAL TUMORSP01CA085799 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI JENKINS, ROBERT B. · 2001 to 2004
$8.1M
PROGRAMS FOR TREATMENT OF MALIGNANT BRAIN TUMORSP01NS042927 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BERGER, MITCHEL S. · 2001 to 2004
$6.7M
The role of microglia and macrophages in the development of brain tumorsK08NS063456 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHILLIPS, JOANNA · 2008 to 2012
$854k
NCI NIH HHS CA85799NCI NIH HHS P01 CA085799NINDS NIH HHS K08 NS063456NINDS NIH HHS NS063456NINDS NIH HHS NS42927NINDS NIH HHS P01 NS042927
6 · The paper itself

Abstract

The pituicytoma is a rare neoplasm whose histogenesis is debated partly because of the diversity of tissue types present in the sellar region. In this article we illustrate the characteristic histologic, immunohistologic, and ultrastructural features of this unique neoplasm. Furthermore, we use array-based comparative genomic hybridization to demonstrate a unique pattern of genomic copy number aberrations in pituicytomas. Tumors were composed of bipolar, spindle cells that were immunopositive for S100, vimentin, and Bcl-2 and immunonegative for synaptophysin, chromogranin, and glial fibrillary acidic protein. Ultrastructural analysis was remarkable for absence of secretory granules. Array comparative genomic hybridization demonstrated genomic copy number imbalances, including losses on chromosome arms 1p, 14q, and 22q and gains on 5p. This pattern of genetic changes only partially overlaps with the genomic alterations reported in pituitary adenomas. In summary, our data suggest that pituicytomas are a unique subset of tumors of the sellar region.

Indexed as

Gene DosageChromosome MappingComparative Genomic HybridizationFemaleHumansImmunohistochemistryMaleMiddle AgedPituitary NeoplasmsRare DiseasesSecretory Vesicles

Identifiers

PMID20586639
PMCPMC3161118

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.