Evidence map›Paper›PMID 20586054›Full record

ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2010

Vasa genes: emerging roles in the germ line and in multipotent cells.

Eric A Gustafson, Gary M Wessel

Open access · greenAbstract read
In one paragraph

Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 172 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eric A GustafsonProvidence Institute of Molecular Oogenesis Department of Molecular Biology, Cell Biology and Biochemistry Brown University Providence, RI 02912, USA.
Gary M Wessel
Brown University · US

Funding

TRAINING IN MOLECULAR &CELL BIOLOGY &BIOCHEMISTRYT32GM007601 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 1985 to 2019
$6.4M
Post-translational Regulation of Germline DeterminantsR01HD028152 · NICHD · BROWN UNIVERSITY · PI WESSEL, GARY M · 1997 to 2016
$3.9M
NICHD NIH HHS R01 HD028152NIGMS NIH HHS T32 GM007601
6 · The paper itself

Abstract

Sexually reproducing metazoans establish a cell lineage during development that is ultimately dedicated to gamete production. Work in a variety of animals suggests that a group of conserved molecular determinants act in this germ line maintenance and function. The most universal of these genes are Vasa and Vasa-like DEAD-box RNA helicase genes. However, recent evidence indicates that Vasa genes also function in other cell types, distinct from the germ line. Here we evaluate our current understanding of Vasa function and its regulation during development, addressing Vasa's emerging role in multipotent cells. We also explore the evolutionary diversification of the N-terminal domain of this gene and how this impacts the association of Vasa with nuage-like perinuclear structures.

Indexed as

AnimalsDEAD-box RNA HelicasesGene Expression Regulation, EnzymologicGerm CellsHumansMultipotent Stem CellsRNA InterferenceDEAD-box RNA Helicases

Identifiers

PMID20586054
PMCPMC3090673
OpenAlexW2161286469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.