ArticleJournal of inherited metabolic disease2010
Congenital toxoplasmosis--a report on the Danish neonatal screening programme 1999-2007.
Article in Journal of inherited metabolic disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study.Scientific reports · 2016Trial
- Anti-Pathogens (Basel, Switzerland) · 2023Review
- Gestational toxoplasmosis treatment changes the child's prognosis: A cohort study in southern Brazil.PLoS neglected tropical diseases · 2023Article
- Antenatal Screening for Toxoplasmosis and Rubella in Saudi Arabia: Assessing the Need for Screening.Journal of multidisciplinary healthcare · 2023Article
- Congenital toxoplasmosis: Should we still care about screening?Food and waterborne parasitology · 2022Article
- Toxoplasmosis Infection in Newborn: A Systematic Review and Meta-analysis.Advanced biomedical research · 2022Review
- The disease burden of ocular toxoplasmosis in Denmark in 2019: Estimates based on laboratory testing of ocular samples and on publicly available register data.Parasite epidemiology and control · 2021Article
- Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings.Food and waterborne parasitology · 2019Review
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis.PloS one · 2019Article
- Article
- Survey of obstetrician-gynecologists in the United States about toxoplasmosis: 2012 update.Archives of gynecology and obstetrics · 2015Article
- Universal newborn screening for congenital CMV infection: what is the evidence of potential benefit?Reviews in medical virology · 2014Review
- Evaluation of a new protocol for retrospective diagnosis of congenital toxoplasmosis by use of Guthrie cards.Journal of clinical microbiology · 2014Article
- Neglected parasitic infections in the United States: toxoplasmosis.The American journal of tropical medicine and hygiene · 2014Article
- Decision analysis, economic evaluation, and newborn screening: challenges and opportunities.Genetics in medicine : official journal of the American College of Medical Genetics · 2013Article
- Epidemiology of and diagnostic strategies for toxoplasmosis.Clinical microbiology reviews · 2012Review
- Investigation and management of Toxoplasma gondii infection in pregnancy and infancy: a prospective study.Acta pharmacologica Sinica · 2011Article
- Newborn screening: how are we travelling, and where should we be going?Journal of inherited metabolic disease · 2011Review
Corrections and comments
- Erratum issuedNørgaard-Pedersen, Peter Bent [corrected to Nørgaard-Pedersen, Bent]
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis paper reports on the national neonatal screening programme for congenital toxoplasmosis (CT) in Denmark conducted from 1999 to 2007, including background, basis for initiation of screening, methods, results, and finally reasons for the discontinuation of the screening.
methodsA nationwide screening was conducted at Statens Serum Institut, including >98% newborns, and using filter paper eluates (Guthrie card, PKU card) obtained from newborns 5-10 days old. These were analysed for Toxoplasma gondii-specific antibodies (IgM), and if positive, then IgM (ISAGA). Confirmatory serology was performed on children and their mothers (IgM, IgG, IgA, dye test) where infection was suspected, and children with suspected or confirmed CT initiated a 3-month treatment regimen with pyrimethamine, sulfadiazine and folinic acid supplements. Selective cohorts were followed with regard to developmental and clinical outcome.
resultsA total of 100 children were diagnosed with CT in the screening period, and only 2 cases were detected outside of the screening programme. CT prevalence was 1.6 per 10,000 live-born infants. Follow-up studies showed new retinochoroidal lesions in affected children despite treatment.
conclusionScreening was terminated August 2007, after it became apparent that no benefit of treatment could be shown. CT was evaluated using a Danish adaptation of the Uniform Screening Panel (ACMG), showing CT as an unlikely candidate for screening today. Whereas results might be comparable with other low-endemic countries with similar strains of T. gondii, neonatal screening and treatment might offer different results in regions with either high prevalence or different strains of T. gondii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.