ArticleCellular and molecular life sciences : CMLS2010
The evolutionary context for a self-nonself discrimination.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Study on the risk identification of abnormal gas outbursts based on the mechanism of biological immunity.Scientific reports · 2025Article
- From seabed to sickbed: lessons gained from allorecognition in marine invertebrates.Frontiers in immunology · 2025Article
- Postpartum hepatitis and host immunity in pregnant women with chronic HBV infection.Frontiers in immunology · 2022Review
- Rationalizing the path to a universal graft recipient.Immunologic research · 2018Review
- T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy.Cancer immunology, immunotherapy : CII · 2018Review
- Learning from a contemporary history of immunology.Immunologic research · 2017Review
- Analysis of Paris meeting redefining the "self" of the immune system.Immunologic research · 2015Article
- A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).Cellular and molecular life sciences : CMLS · 2014Review
- Towards a liquid self: how time, geography, and life experiences reshape the biological identity.Frontiers in immunology · 2014Article
- Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- Comment on: Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
This essay was written to illustrate how one might think about the immune system. The formulation of valid theories is the basic component of how-to-think because the reduction of large and complex data sets by the use of logic into a succinct model with predictability and explanatory power, is the only way that we have to arrive at "understanding". Whether it is to achieve effective manipulation of the system or for pure pleasure, "understanding" is a universally agreed upon goal. It is in the nature of science that theories are there to be disproven. An experimentally disproven theory is a successful one. As they fail experimental test one by one, we end up with a default theory, that is, one that has yet to fail. Here, using the self-nonself discrimination as an example, how-to-think as I see it, will be illustrated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.