ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
MGMT gene promoter methylation in pediatric glioblastomas.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 41 citations in OpenAlex.
- Impact of tumor location and pathological discordance on survival of children with midline high-grade gliomas treated on Children's Cancer Group high-grade glioma study CCG-945.Journal of neuro-oncology · 2015Trial
- Circadian rhythms in pediatric high-grade gliomas may contribute to treatment efficacy.Scientific reports · 2025Article
- Review
- The molecular oncology of bilateral high-grade thalamic astrocytomas in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells.International journal of molecular medicine · 2018Article
- Extent of surgical resection and adjuvant temozolomide improves survival in pediatric GBM: a single center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Clinical outcome and molecular characterization of pediatric glioblastoma treated with postoperative radiotherapy with concurrent and adjuvant temozolomide: a single institutional study of 66 children.Neuro-oncology practice · 2016Article
- Pediatric glioblastoma: a single institution experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Pediatric gliosarcoma treated with adjuvant radiotherapy and temozolomide.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment.BioMed research international · 2015Review
- Article
- Management of high-grade gliomas in the pediatric patient: Past, present, and future.Neuro-oncology practice · 2014Article
- Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.Nature reviews. Cancer · 2014Review
- Using the molecular classification of glioblastoma to inform personalized treatment.The Journal of pathology · 2014Review
- MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- MGMT promoter methylation in pediatric high-grade gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Article
- Outcomes of pediatric glioblastoma treated with adjuvant chemoradiation with temozolomide and correlation with prognostic factors.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyArticle
- Prognostic Significance and Clinicopathological Correlations of Epigenetic MGMT Gene Silencing in High Grade Diffuse Gliomas.Discoveries (Craiova, Romania)Article
- Therapeutic approach beyond conventional temozolomide for newly diagnosed glioblastoma: Review of the present evidence and future direction.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric OncologyReview
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRelatively few studies have been performed on molecular properties of pediatric glioblastoma multiforme (GBM). Methylation of DNA repair gene O(6)-methylguanine-DNA methyltransferase (MGMT) promoter region has been associated with favorable prognosis and prolonged survival in adult GBM patients treated with temozolomide (TMZ). We explored the frequency of MGMT gene promoter methylation in pediatric glioblastomas and compared it with the known molecular alterations in p53.
methodsTwenty pediatric GBM cases were selected. MGMT promoter methylation was assessed by methylation specific PCR. p53 expression was determined by immunohistochemistry.
resultsMGMT gene promoter methylation was observed in 50% of pediatric glioblastomas. p53 protein expression was detected in 60% of cases. Seventy percent of cases with methylated MGMT promoter were p53 immunopositive.
conclusionsThe frequency of MGMT gene promoter methylation in pediatric GBMs was similar to adult GBM patients. The pediatric GBMs should also be investigated for MGMT promoter methylation to identify a subset of patients likely to benefit from TMZ therapy. p53 protein overexpression was more common in pediatric primary GBMs. To the best of our knowledge this is only the second study on MGMT gene promoter methylation status in pediatric GBMs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.