Evidence map›Paper›PMID 20585761›Full record

Trial reportPsychopharmacology2010

Nicotine and food deprivation decrease the ability to resist smoking.

Robert F Leeman, Stephanie S O'Malley, Marney A White, Sherry A McKee

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interventions for preventing weight gain after smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Trial
  3. Trial
  4. Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Trial
  5. Trial
  6. Trial
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  8. Trial
  9. Trial
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  11. Dependence and withdrawal-induced craving predict abstinence in an incentive-based model of smoking relapse.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
    Trial
  12. Trial
  13. Article
  14. Article
  15. Designing Religiously Informed and Culturally Acceptable Tobacco Cessation Interventions for UK-Based Muslims.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  16. Article
  17. Article
  18. Identifying Novel Motivation Phase-Specific Cessation Targets for Youth Experiencing Homelessness in the United States.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert F LeemanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. robert.leeman@yale.edu
Stephanie S O'Malley
Marney A White
Sherry A McKee

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Tobacco Dependence &Risk Factors for Treatment FailureP50AA015632 · NIAAA · YALE UNIVERSITY · PI MAZURE, CAROLYN M. · 2004 to 2008
$9.2M
Research Training Fellowship in Substance use and Addiction (RTFSA)T32DA007238 · NIDA · YALE UNIVERSITY · PI BRIAN D. KILUK, ISMENE L. PETRAKIS · 1988 to 2026
$5.7M
Improving Alcoholism TreatmentK05AA014715 · NIAAA · YALE UNIVERSITY · PI O'MALLEY, STEPHANIE S · 2004 to 2013
$2.1M
Modeling Stress-Precipitated Smoking Lapse for Medication Development (9 of 14)RL1DA024857 · NIDA · YALE UNIVERSITY · PI MCKEE, SHERRY ANN · 2007 to 2011
$1.3M
Craving, Binge Eating, and ObesityK23DK071646 · NIDDK · YALE UNIVERSITY · PI WHITE, MARNEY A · 2005 to 2009
$673k
NCRR NIH HHS UL1 RR024139NIAAA NIH HHS K05 AA014715NIAAA NIH HHS P50 AA015632NIDA NIH HHS RL1 DA024857NIDA NIH HHS T32 DA007238NIDA NIH HHS T32 DA07238NIDDK NIH HHS K23 DK071646
6 · The paper itself

Abstract

rationaleAttempts to simultaneously control food intake and smoking may lead to smoking cessation failure. We sought to model this relationship using a human laboratory paradigm of smoking lapse behavior.

objectivesWe examined the combined effect of food and nicotine deprivation, compared to nicotine deprivation alone, on the ability to resist smoking and on subsequent ad libitum smoking.

methodsIn a between-subjects design, daily smokers (N = 30) were all deprived of nicotine for 18 h and were either food-deprived (12 h) or not during a laboratory session. Following exposure to individualized food cues, participants had the option of initiating tobacco self-administration or delaying up to 50 min in exchange for monetary reinforcement. Subsequently, the tobacco self-administration period consisted of 1 h in which participants could choose to smoke or receive monetary reinforcement for cigarettes not smoked.

resultsSmokers who had been deprived of food and nicotine smoked their first cigarette sooner and were more likely to smoke at some point during the laboratory session, compared to those who were only nicotine-deprived. Those who were food- and nicotine-deprived smoked slightly more cigarettes than those who were nicotine-deprived only, although this difference was not statistically significant. There were no sex differences in outcomes. Hunger and food craving ratings while trying to resist smoking were greater in the food + nicotine-deprived group. Tobacco craving was predictive of outcome in both conditions.

conclusionsThese findings support the hypothesis that food deprivation can undermine a smoker's ability to resist smoking.

Indexed as

Food DeprivationAdultFemaleGanglionic StimulantsHumansMaleNicotineReinforcement, PsychologySelf AdministrationSmokingSmoking CessationYoung AdultGanglionic StimulantsNicotine

Identifiers

PMID20585761
PMCPMC3111597

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.