ArticlePloS one2010
The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Type II bacterial toxin-antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system.FEMS microbiology reviews · 2023Article
- Interactions of theMicroorganisms · 2021Article
- Review
- Identification of integrative and conjugative elements in pathogenic and commensalMicrobial genomics · 2020Article
- TheToxins · 2018Article
- Toxin-Antitoxin Systems in Clinical Pathogens.Toxins · 2016Review
- Comparative Genomics of Carriage and Disease Isolates of Streptococcus pneumoniae Serotype 22F Reveals Lineage-Specific Divergence and Niche Adaptation.Genome biology and evolution · 2016Article
- The Streptococcus pneumoniae pezAT Toxin-Antitoxin System Reduces β-Lactam Resistance and Genetic Competence.Frontiers in microbiology · 2016Article
- Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis.Scientific reports · 2015Article
- One cannot rule them all: Are bacterial toxins-antitoxins druggable?FEMS microbiology reviews · 2015Review
- Activation of Toxin-Antitoxin System Toxins Suppresses Lethality Caused by the Loss of σE in Escherichia coli.Journal of bacteriology · 2015Article
- Expression of the Streptococcus pneumoniae yoeB chromosomal toxin gene causes cell death in the model plant Arabidopsis thaliana.BMC biotechnology · 2015Article
- Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon.Frontiers in microbiology · 2014Article
- Detection of endogenous MazF enzymatic activity in Staphylococcus aureus.Analytical biochemistry · 2013Article
- Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many.Microbiology and molecular biology reviews : MMBR · 2012Review
- Artificial activation of toxin-antitoxin systems as an antibacterial strategy.Trends in microbiology · 2012Review
- Article
- Evolutionary, ecological and biotechnological perspectives on plasmids resident in the human gut mobile metagenome.Bioengineered bugs · 2012Review
- Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae.Journal of bacteriology · 2011Article
- A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.PLoS biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Type II (proteic) chromosomal toxin-antitoxin systems (TAS) are widespread in Bacteria and Archaea but their precise function is known only for a limited number of them. Out of the many TAS described, the relBE family is one of the most abundant, being present in the three first sequenced strains of Streptococcus pneumoniae (D39, TIGR4 and R6). To address the function of the pneumococcal relBE2Spn TAS in the bacterial physiology, we have compared the response of the R6-relBE2Spn wild type strain with that of an isogenic derivative, Delta relB2Spn under different stress conditions such as carbon and amino acid starvation and antibiotic exposure. Differences on viability between the wild type and mutant strains were found only when treatment directly impaired protein synthesis. As a criterion for the permanence of this locus in a variety of clinical strains, we checked whether the relBE2Spn locus was conserved in around 100 pneumococcal strains, including clinical isolates and strains with known genomes. All strains, although having various types of polymorphisms at the vicinity of the TA region, contained a functional relBE2Spn locus and the type of its structure correlated with the multilocus sequence type. Functionality of this TAS was maintained even in cases where severe rearrangements around the relBE2Spn region were found. We conclude that even though the relBE2Spn TAS is not essential for pneumococcus, it may provide additional advantages to the bacteria for colonization and/or infection.
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