ArticlePloS one2010
Involvement of C4 protein of beet severe curly top virus (family Geminiviridae) in virus movement.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Characterization of the C4 protein encoded by parsley yellow leaf curl virus.Virology journal · 2026Article
- Tomato Yellow Leaf Curl Virus C4 Suppresses Antiviral Immunity by Targeting the 14-3-3 Protein SlTFT2.Molecular plant pathology · 2026Article
- Virus-Inducible Activation of Hypersensitive Response Confers Broad-Spectrum Resistance to Diverse Viruses in Plants.Molecular plant pathology · 2025Article
- Role of complementary-sense genes and intergenic region of beet curly top virus in intermolecular recombination frequency upon local infection in plants.Journal of virology · 2025Article
- Meta-transcriptomic analysis reveals the geographical expansion of known sugarbeet-infecting viruses and the occurrence of a novel virus in sugarbeet in the United States.Frontiers in plant science · 2024Article
- Article
- The identification of the methylation patterns of tomato curly stunt virus in resistant and susceptible tomato lines.Frontiers in plant science · 2023Article
- Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana.PLoS pathogens · 2022Article
- Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis.Archives of virology · 2022Review
- Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.PLoS pathogens · 2021Review
- Positive selection and intrinsic disorder are associated with multifunctional C4(AC4) proteins and geminivirus diversification.Scientific reports · 2021Article
- Regulatory Roles of Small Non-coding RNAs in Sugar Beet Resistance AgainstFrontiers in plant science · 2021Article
- Plant-virus-insect tritrophic interactions: insights into the functions of geminivirus virion-sense strand genes.Proceedings. Biological sciences · 2020Article
- Tomato auxin biosynthesis/signaling is reprogrammed by the geminivirus to enhance its pathogenicity.Planta · 2020Article
- Phosphorylations of the Abutilon Mosaic Virus Movement Protein Affect Its Self-Interaction, Symptom Development, Viral DNA Accumulation, and Host Range.Frontiers in plant science · 2020Article
- C4, the Pathogenic Determinant ofFrontiers in microbiology · 2020Article
- Geminivirus-Encoded Proteins: Not All Positional Homologs Are Made Equal.Frontiers in microbiology · 2020Article
- Analysis of Pathogenicity and Virulence Factors ofFrontiers in plant science · 2020Article
- Plant Antiviral Immunity Against Geminiviruses and Viral Counter-Defense for Survival.Frontiers in microbiology · 2019Review
- TheFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeet severe curly top virus (BSCTV) is a leafhopper transmitted geminivirus with a monopartite genome. C4 proteins encoded by geminivirus play an important role in virus/plant interaction. METHODS AND
findingsTo understand the function of C4 encoded by BSCTV, two BSCTV mutants were constructed by introducing termination codons in ORF C4 without affecting the amino acids encoded by overlapping ORF Rep. BSCTV mutants containing disrupted ORF C4 retained the ability to replicate in Arabidopsis protoplasts and in the agro-inoculated leaf discs of N. benthamiana, suggesting C4 is not required for virus DNA replication. However, both mutants did not accumulate viral DNA in newly emerged leaves of inoculated N. benthamiana and Arabidopsis, and the inoculated plants were asymptomatic. We also showed that C4 expression in plant could help C4 deficient BSCTV mutants to move systemically. C4 was localized in the cytosol and the nucleus in both Arabidopsis protoplasts and N. benthamiana leaves and the protein appeared to bind viral DNA and ds/ssDNA nonspecifically, displaying novel DNA binding properties.
conclusionsOur results suggest that C4 protein in BSCTV is involved in symptom production and may facilitate virus movement instead of virus replication.
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