ArticlePLoS pathogens2010
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 86 citations in OpenAlex.
- AMPK activation by hepatitis E virus infection inhibits viral replication through attenuation of autophagosomes and promotion of innate immunity.Cellular and molecular life sciences : CMLS · 2025Article
- Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62.The Journal of cell biology · 2024Article
- Effects of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins on Hepatocellular Carcinoma Cells.International journal of molecular sciences · 2023Article
- Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens.PLoS pathogens · 2022Article
- Review
- AMP-activated kinase regulates porcine reproductive and respiratory syndrome virus infection in vitro.Virus genes · 2022Article
- Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways.Sub-cellular biochemistry · 2022Review
- Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Article
- Multifaceted Role of AMPK in Viral Infections.Cells · 2021Review
- Predicting host dependency factors of pathogens inComputational and structural biotechnology journal · 2021Article
- Possible roles of AMPK and macropinocytosis in the defense responses against ΔToxicology reports · 2021Article
- Article
- From Cell Entry to Engraftment of Exogenous Mitochondria.International journal of molecular sciences · 2020Review
- The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication.The Journal of biological chemistry · 2020Article
- Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs.Pharmaceuticals (Basel, Switzerland) · 2019Review
- IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.Molecular biology of the cell · 2019Article
- Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.Cell metabolism · 2019Article
- PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.Cancer discovery · 2018Article
- p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila.PLoS pathogens · 2018Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Poxviruses include medically important human pathogens, yet little is known about the specific cellular factors essential for their replication. To identify genes essential for poxvirus infection, we used high-throughput RNA interference to screen the Drosophila kinome for factors required for vaccinia infection. We identified seven genes including the three subunits of AMPK as promoting vaccinia infection. AMPK not only facilitated infection in insect cells, but also in mammalian cells. Moreover, we found that AMPK is required for macropinocytosis, a major endocytic entry pathway for vaccinia. Furthermore, we show that AMPK contributes to other virus-independent actin-dependent processes including lamellipodia formation and wound healing, independent of the known AMPK activators LKB1 and CaMKK. Therefore, AMPK plays a highly conserved role in poxvirus infection and actin dynamics independent of its role as an energy regulator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.