ArticlePloS one2010
The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Molecular mechanisms underlyingFrontiers in cellular and infection microbiology · 2026Review
- Single-cell map of innate-like lymphocyte response toiScience · 2025Article
- The immune response toFrontiers in microbiology · 2025Review
- Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.Infection and immunity · 2021Article
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- Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis.Frontiers in immunology · 2019Review
- AFrontiers in microbiology · 2019Article
- Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.Journal of immunology research · 2019Review
- The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.Mediators of inflammation · 2019Article
- ADAR1-mediated regulation of melanoma invasion.Nature communications · 2018Article
- Interleukin 1α (IL-1α) Promotes Pathogenic Immature Myeloid Cells and IL-1β Favors Protective Mature Myeloid Cells During Acute Lung Infection.The Journal of infectious diseases · 2018Article
- Adaptive Immunity toFrontiers in cellular and infection microbiology · 2018Review
- Interleukin 17 is a chief orchestrator of immunity.Nature immunology · 2017Review
- Article
- Defective IL-17- and IL-22-dependent mucosal host response to Candida albicans determines susceptibility to oral candidiasis in mice expressing the HIV-1 transgene.BMC immunology · 2014Article
- Article
- Article
- T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs.Infection and immunity · 2014Article
- Does Type I Interferon Limit Protective Neutrophil Responses during Pulmonary Francisella Tularensis Infection?Frontiers in immunology · 2014Review
- Host-pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicity.Infection and drug resistance · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrancisella tularensis is an intercellular bacterium often causing fatal disease when inhaled. Previous reports have underlined the role of cell-mediated immunity and IFNgamma in the host response to Francisella tularensis infection. METHODOLOGY/PRINCIPAL
findingsHere we provide evidence for the involvement of IL-17A in host defense to inhalational tularemia, using a mouse model of intranasal infection with the Live Vaccine Strain (LVS). We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary gammadelta and Th17 cells. The peak of IL-17A production appears early during sub-lethal infection, it precedes the peak of immune activation and the nadir of the disease, and then subsides subsequently. Exogenous airway administration of IL-17A or of IL-23 had a limited yet consistent effect of delaying the onset of death from a lethal dose of LVS, implying that IL-17A may be involved in restraining the infection. The protective role for IL-17A was directly demonstrated by in vivo neutralization of IL-17A. Administration of anti IL-17A antibodies concomitantly to a sub-lethal airway infection with 0.1xLD(50) resulted in a fatal disease.
conclusionIn summary, these data characterize the involvement and underline the protective key role of the IL-17A axis in the lungs from inhalational tularemia.
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