ArticleDose-response : a publication of International Hormesis Society2009
Low-dose cancer risk modeling must recognize up-regulation of protection.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03597360 (Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia), which is not on this map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia (LDIR-CT-AD) Trial: A Pilot Study
Who cites it
41 citing papers in PubMed.
- Insights into the Impact of Low-Dose Ionizing Radiation on Neurodegenerative Disease Progression in In Vivo Models.International journal of molecular sciences · 2026Review
- Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies.Molecular cancer · 2026Review
- Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition.International journal of molecular sciences · 2026Review
- Structural and temporal dynamics analysis on immune response in low-dose radiation: History, research hotspots and emerging trends.World journal of radiology · 2025Article
- Assessment of Radiation Hazard Indices Due to Natural Radionuclides in Soil Samples from Imo State University, Owerri, Nigeria.Environmental health insights · 2024Article
- Chrysin Encapsulated Copper Nanoparticles with Low Dose of Gamma Radiation Elicit Tumor Cell Death Through p38 MAPK/NF-κB Pathways.Biological trace element research · 2023Article
- Marine Bacteria under Low-Intensity Radioactive Exposure: Model Experiments.International journal of molecular sciences · 2022Review
- Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity.Heliyon · 2020Article
- Selenium-binding protein 1 is down-regulated in malignant melanoma.Oncotarget · 2018Article
- Cancer immunotherapy: how low-level ionizing radiation can play a key role.Cancer immunology, immunotherapy : CII · 2017Review
- Comparative Analysis of Whole-Genome Gene Expression Changes in Cultured Human Embryonic Stem Cells in Response to Low, Clinical Diagnostic Relevant, and High Doses of Ionizing Radiation Exposure.International journal of molecular sciences · 2015Article
- Point/Counterpoint: low-dose radiation is beneficial, not harmful.Medical physics · 2014Article
- Correcting systemic deficiencies in our scientific infrastructure.Dose-response : a publication of International Hormesis Society · 2014Article
- Low dose radiation adaptive protection to control neurodegenerative diseases.Dose-response : a publication of International Hormesis Society · 2014Article
- Commentary: ethical issues of current health-protection policies on low-dose ionizing radiation.Dose-response : a publication of International Hormesis Society · 2014Article
- Remedy for radiation fear - discard the politicized science.Dose-response : a publication of International Hormesis Society · 2014Article
- Linear No-Threshold Model VS. Radiation Hormesis.Dose-response : a publication of International Hormesis Society · 2013Article
- Commentary on fukushima and beneficial effects of low radiation.Dose-response : a publication of International Hormesis Society · 2013Article
- A stochastic markov model of cellular response to radiation.Dose-response : a publication of International Hormesis Society · 2011Article
- Residential radon appears to prevent lung cancer.Dose-response : a publication of International Hormesis Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
IONIZING RADIATION PRIMARILY PERTURBS THE BASIC MOLECULAR LEVEL PROPORTIONAL TO DOSE, WITH POTENTIAL DAMAGE PROPAGATION TO HIGHER LEVELS: cells, tissues, organs, and whole body. There are three types of defenses against damage propagation. These operate deterministically and below a certain impact threshold there is no propagation. Physical-static defenses precede metabolic-dynamic defenses acting immediately: scavenging of toxins; - molecular repair, especially of DNA; - removal of damaged cells either by apoptosis, necrosis, phagocytosis, cell differentiation-senescence, or by immune responses, - followed by replacement of lost elements. Another metabolic-dynamic defense arises delayed by up-regulating immediately operating defense mechanisms. Some of these adaptive protections may last beyond a year and all create temporary protection against renewed potentially toxic impacts also from non-radiogenic endogenous sources. Adaptive protections have a maximum after single tissue absorbed doses around 100 to 200 mSv and disappear with higher doses. Low dose rates initiate maximum protection likely at lower cell doses delivered repetitively at certain time intervals. Adaptive protection preventing only about 2 - 3 % of endogenous life-time cancer risk would fully balance a calculated induced cancer risk at about 100 mSv, in agreement with epidemiological data and concordant with an hormetic effect. Low-dose-risk modeling must recognize up-regulation of protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.