ArticleDose-response : a publication of International Hormesis Society2009
Immunological mechanism of the low-dose radiation-induced suppression of cancer metastases in a mouse model.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanistic Effects of Environmental and Medical Low-Dose Radiation Exposure of the Lung.Biomedicines · 2026Review
- Challenging the Mutation-Only Paradigm: Evidence from Ramsar High Background Radiation Areas.Journal of biomedical physics & engineering · 2025Article
- Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors.Oncoimmunology · 2023Review
- Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats.Environmental science and pollution research international · 2021Article
- Recovery kinetics of micronucleus formation by fractionated X-ray irradiation in various types of human cells.Journal of radiation research · 2018Article
- Effect of internal contamination with tritiated water on the neoplastic colonies in the lungs, innate anti-tumour reactions, cytokine profile, and haematopoietic system in radioresistant and radiosensitive mice.Radiation and environmental biophysics · 2018Article
- Immunological mechanism of low-dose priming radiation resistance in walker-256 tumor model mice.Experimental and therapeutic medicine · 2017Article
- Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.Molecular imaging and biology · 2017Review
- Cancer immunotherapy: how low-level ionizing radiation can play a key role.Cancer immunology, immunotherapy : CII · 2017Review
- Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy.Journal of cell communication and signaling · 2014Article
- Linear No-Threshold Model VS. Radiation Hormesis.Dose-response : a publication of International Hormesis Society · 2013Article
- Potential treatment of inflammatory and proliferative diseases by ultra-low doses of ionizing radiations.Dose-response : a publication of International Hormesis Society · 2012Article
- Effect of low doses of low-let radiation on the innate anti-tumor reactions in radioresistant and radiosensitive mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Shifting the paradigm in radiation safety.Dose-response : a publication of International Hormesis Society · 2012Article
- The effects of low-dose ionizing radiation in the activated rat basophilic leukemia (RBL-2H3) mast cells.The Journal of biological chemistry · 2012Article
- The healthy worker effect and nuclear industry workers.Dose-response : a publication of International Hormesis Society · 2010Article
- Special issue introduction.Dose-response : a publication of International Hormesis Society · 2010Article
- Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation: Three Case Reports.Dose-response : a publication of International Hormesis SocietyArticle
- Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the doctrine underlying the current radiation protection regulations each, no matter how small, exposure to ionizing radiation may be carcinogenic. However, numerous epidemiological observations demonstrate that cancer incidence and/or mortality are not elevated among inhabitants of the high- versus low-natural-background radiation areas and homes. Results of our own and other authors' studies described in this paper bear testimony to the possibility that stimulation of the anti-neoplastic immune surveillance mediated by NK lymphocytes and activated macrophages explains, at least partially, the accumulating epidemiological and experimental evidence indicating that low-level exposures to the low-linear energy transfer (LET) radiation inhibit the development of spontaneous and artificial metastases in humans and laboratory animals, respectively. The results presented also suggest the possibility of using low-level X- and gamma-ray exposures to cure cancer and to prevent cancer metastases. For a broader perspective, the results presented may help towards relaxing the current radiation protection regulations, especially as they apply to diagnostic and therapeutic exposures of patients to the indicated forms of radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.