ArticlePloS one2010
Sympatric and allopatric divergence of MHC genes in threespine stickleback.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Genomic Signatures of Speciation in Butterflies.Systematic biology · 2026Article
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- Diversifying selection and climatic effects on major histocompatibility complex class II gene diversity in the greater horseshoe bat.Evolutionary applications · 2023Article
- Ecological Speciation Promoted by Divergent Regulation of Functional Genes Within African Cichlid Fishes.Molecular biology and evolution · 2022Article
- What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback?Molecular ecology · 2021Article
- Scale-dependent effects of host patch traits on species composition in a stickleback parasite metacommunity.Ecology · 2020Article
- Analysis of structural variants in four African cichlids highlights an association with developmental and immune related genes.BMC evolutionary biology · 2020Article
- An exploration of the links between parasites, trophic ecology, morphology, and immunogenetics in the Lake Tanganyika cichlid radiation.Hydrobiologia · 2019Article
- MHC diversity and female age underpin reproductive success in an Australian icon; the Tasmanian Devil.Scientific reports · 2018Article
- Innate immune responses to gut microbiota differ between oceanic and freshwater threespine stickleback populations.Disease models & mechanisms · 2016Article
- Testing for Local Adaptation to Spawning Habitat in Sympatric Subpopulations of Pike by Reciprocal Translocation of Embryos.PloS one · 2016Article
- Isolation over 35 years in a heated biotest basin causes selection on MHC class IIß genes in the European perch (Perca fluviatilis L.).Ecology and evolution · 2015Article
- Maintaining microendemic primate species along an environmental gradient - parasites as drivers for species differentiation.Ecology and evolution · 2014Article
- Host-parasite interactions and the evolution of nonrandom mating.Evolution; international journal of organic evolution · 2014Article
- Diversity and relative abundance of the bacterial pathogen, Flavobacterium spp., infecting reproductive ecotypes of kokanee salmon.BMC research notes · 2014Article
- Evolution of genomic structural variation and genomic architecture in the adaptive radiations of African cichlid fishes.Frontiers in genetics · 2014Article
- Immune-related functions of the Hivep gene family in East African cichlid fishes.G3 (Bethesda, Md.) · 2013Article
- Water temperature, not fish morph, determines parasite infections of sympatric Icelandic threespine sticklebacks (Gasterosteus aculeatus).Ecology and evolution · 2013Article
- Differentiation at the MHCIIα and Cath2 loci in sympatric Salvelinus alpinus resource morphs in Lake Thingvallavatn.PloS one · 2013Article
- Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasites can strongly affect the evolution of their hosts, but their effects on host diversification are less clear. In theory, contrasting parasite communities in different foraging habitats could generate divergent selection on hosts and promote ecological speciation. Immune systems are costly to maintain, adaptable, and an important component of individual fitness. As a result, immune system genes, such as those of the Major Histocompatibility Complex (MHC), can change rapidly in response to parasite-mediated selection. In threespine stickleback (Gasterosteus aculeatus), as well as in other vertebrates, MHC genes have been linked with female mating preference, suggesting that divergent selection acting on MHC genes might influence speciation. Here, we examined genetic variation at MHC Class II loci of sticklebacks from two lakes with a limnetic and benthic species pair, and two lakes with a single species. In both lakes with species pairs, limnetics and benthics differed in their composition of MHC alleles, and limnetics had fewer MHC alleles per individual than benthics. Similar to the limnetics, the allopatric population with a pelagic phenotype had few MHC alleles per individual, suggesting a correlation between MHC genotype and foraging habitat. Using a simulation model we show that the diversity and composition of MHC alleles in a sympatric species pair depends on the amount of assortative mating and on the strength of parasite-mediated selection in adjacent foraging habitats. Our results indicate parallel divergence in the number of MHC alleles between sympatric stickleback species, possibly resulting from the contrasting parasite communities in littoral and pelagic habitats of lakes.
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