ArticleMolecular psychiatry2011
Genome-wide association study of conduct disorder symptomatology.
Article in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.Nature communications · 2021Pooled it
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression.Molecular psychiatry · 2014Pooled it
- Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.PLoS genetics · 2013Pooled it
- The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors.PloS one · 2022Trial
- The interplay between externalizing disorders polygenic risk scores and contextual factors on the development of marijuana use disorders.Drug and alcohol dependence · 2018Trial
- Evaluating the genetic susceptibility to peer reported bullying behaviors.Psychiatry research · 2018Trial
- Developmental emergence of cortical neurogliaform cell diversity.Development (Cambridge, England) · 2023Article
- Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.Cardiovascular research · 2022Article
- The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases.Genes & diseases · 2022Review
- Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection.Journal of molecular biology · 2022Review
- Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.Annals of neurology · 2021Article
- Prosocial and Aggressive Behavior: A Longitudinal Study.Monographs of the Society for Research in Child Development · 2021Article
- Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males.Biomolecules · 2020Article
- Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder.European child & adolescent psychiatry · 2020Article
- Etiopathogenetic Mechanisms in Diverticular Disease of the Colon.Cellular and molecular gastroenterology and hepatology · 2020Review
- 22q11.2 duplication: a review of neuropsychiatric correlates and a newly observed case of prototypic sociopathy.Cold Spring Harbor molecular case studies · 2019Review
- Comorbidity of bipolar I disorder and conduct disorder: a familial risk analysis.Acta psychiatrica Scandinavica · 2019Article
- Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Testing gene by community disadvantage moderation of sexual health outcomes among urban women.PloS one · 2019Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Conduct disorder (CD) is one of the most prevalent childhood psychiatric conditions, and is associated with a number of serious concomitant and future problems. CD symptomatology is known to have a considerable genetic component, with heritability estimates in the range of 50%. Despite this, there is a relative paucity of studies aimed at identifying genes involved in the susceptibility to CD. In this study, we report results from a genome-wide association study of CD symptoms. CD symptoms were retrospectively reported by a psychiatric interview among a sample of cases and controls, in which cases met the criteria for alcohol dependence. Our primary phenotype was the natural log transformation of the number of CD symptoms that were endorsed, with data available for 3963 individuals who were genotyped on the Illumina Human 1M beadchip array. Secondary analyses are presented for case versus control status, in which caseness was established as endorsing three or more CD symptoms (N = 872 with CD and N = 3091 without CD). We find four markers that meet the criteria for genome-wide significance (P<5 × 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7). There were six additional SNPs in the gene that yielded converging evidence of association. These data provide the first evidence of a specific gene that is associated with CD symptomatology. None of the top signals resided in traditional candidate genes, underscoring the importance of a genome-wide approach for identifying novel variants involved in this serious childhood disorder.
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