ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- The Phospholipase AJournal of lipid and atherosclerosis · 2026Review
- Old but New: Group IIA Phospholipase AMetabolites · 2022Review
- Secretory Phospholipase A2s in Insulin Resistance and Metabolism.Frontiers in endocrinology · 2021Review
- Updating Phospholipase ABiomolecules · 2020Review
- Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.The Journal of biological chemistry · 2016Article
- Metabolic regulation by secreted phospholipase AInflammation and regeneration · 2016Review
- The Roles of the Secreted Phospholipase AAdvances in immunology · 2016Review
- A new era of secreted phospholipase A₂.Journal of lipid research · 2015Article
- Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis.The Journal of biological chemistry · 2015Article
- Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol.BMC genomics · 2015Article
- Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.The Journal of biological chemistry · 2014Article
- Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.Molecular cancer · 2013Article
- Liver X receptors and fat cell metabolism.International journal of obesity (2005) · 2012Review
- Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.The Journal of biological chemistry · 2011Article
- Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.The Journal of biological chemistry · 2011Article
- Integrated lipidomics in the secreted phospholipase A(2) biology.International journal of molecular sciences · 2011Review
- Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- The Role of Phospholipase A(2)-derived Mediators in Obesity.Drug discovery today. Disease mechanisms · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Studies in vitro indicate that group X secretory phospholipase A(2) (GX sPLA(2)) potently releases arachidonic acid (AA) and lysophosphatidylcholine from mammalian cell membranes. To define the function of GX sPLA(2) in vivo, our laboratory recently generated C57BL/6 mice with targeted deletion of GX sPLA(2) (GX(-/-) mice). When fed a normal rodent diet, GX(-/-) mice gained significantly more weight and had increased adiposity compared to GX(+/+) mice, which was not attributable to alterations in food consumption or energy expenditure. When treated with adipogenic stimuli ex vivo, stromal vascular cells isolated from adipose tissue of GX(-/-) mice accumulated significantly more (20%) triglyceride compared to cells from GX(+/+) mice. Conversely, overexpression of GX sPLA(2), but not catalytically inactive GX sPLA(2), resulted in a significant 50% reduction in triglyceride accumulation in OP9 adipocytes. The induction of genes encoding adipogenic proteins (PPARγ, SREBP-1c, SCD1, and FAS) was also significantly blunted by 50-80% in OP9 cells overexpressing GX sPLA(2). Activation of the liver X receptor (LXR), a nuclear receptor known to up-regulate adipogenic gene expression, was suppressed in 3T3-L1 and OP9 cells when GX sPLA(2) was overexpressed. Thus, hydrolytic products generated by GX sPLA(2) negatively regulate adipogenesis, possibly by suppressing LXR activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.