ArticleMolecular & cellular proteomics : MCP2010
Alterations of the salivary secretory peptidome profile in children affected by type 1 diabetes.
Article in Molecular & cellular proteomics : MCP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- Impact of Proline-Rich Salivary Proteins on Interactions between Catechin and Polysaccharides.Journal of agricultural and food chemistry · 2026Article
- Salivary C-Reactive Protein: A Non-Invasive Alternative to Serum CRP in Pediatric Acute Appendicitis.Molecules (Basel, Switzerland) · 2025Article
- Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics.International journal of molecular sciences · 2025Review
- Omics to Unveil Diabetes Mellitus Pathogenesis and Biomarkers: Focus on Proteomics, Lipidomics, and Metabolomics.Advances in experimental medicine and biology · 2024Review
- The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms.International journal of molecular sciences · 2023Review
- Diagnostic Accuracy of Leucine-Rich α-2-Glycoprotein 1 as a Non-Invasive Salivary Biomarker in Pediatric Appendicitis.International journal of molecular sciences · 2023Article
- Qualitative and Quantitative Mass Spectrometry in Salivary Metabolomics and Proteomics.Metabolites · 2023Review
- Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis.Clinical oral investigations · 2022Article
- Salivary Metabolomics of Well and Poorly Controlled Type 1 and Type 2 Diabetes.International journal of dentistry · 2022Article
- Diabetic wound healing in soft and hard oral tissues.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Saliva, a bodily fluid with recognized and potential diagnostic applications.Journal of separation science · 2021Review
- Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes.Proteomes · 2021Article
- Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study.International journal of dentistry · 2021Article
- The Serum and Saliva Proteome of Dogs with Diabetes Mellitus.Animals : an open access journal from MDPI · 2020Article
- Salivary biomarker for acute appendicitis in children: a pilot study.Pediatric surgery international · 2020Article
- RP-HPLC-ESI-IT Mass Spectrometry Reveals Significant Variations of the Human Salivary Protein Profile Associated with Predominantly Antibody Deficiencies.Journal of clinical immunology · 2020Article
- Bitter-Induced Salivary Proteins Increase Detection Threshold of Quinine, But Not Sucrose.Chemical senses · 2019Article
- Saliva Proteomics Analysis Offers Insights on Type 1 Diabetes Pathology in a Pediatric Population.Frontiers in physiology · 2018Article
- A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS.PloS one · 2016Observational
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acidic soluble fraction of whole saliva of type 1 diabetic children was analyzed by reversed phase (RP)(1)-HPLC-ESI-MS and compared with that of sex- and age-matched control subjects. Salivary acidic proline-rich phosphoproteins (aPRP), histatins, α-defensins, salivary cystatins, statherin, proline-rich peptide P-B (P-B), beta-thymosins, S100A8 and S100A9*(S100A9* corresponds to S100A9 vairant lacking the first four amino acids), as well some naturally occurring peptides derived from salivary acidic proline-rich phosphoproteins, histatins, statherin, and P-B peptide, were detected and quantified on the basis of the extracted ion current peak area. The level of phosphorylation of salivary acidic proline-rich phosphoproteins, histatin-1 (Hst-1), statherin and S100A9* and the percentage of truncated forms of salivary acidic proline-rich phosphoproteins was also determined in the two groups. The study revealed that statherin, proline-rich peptide P-B, P-C peptide, and histatins, were significantly less concentrated in saliva of diabetic subjects than in controls, while concentration of α-defensins 1, 2 and 4 and S100A9* was higher. The low concentration of P-C peptide was paralleled by high levels of some of its fragments. On the whole, the study highlighted the severe impairment of the repertoire of peptides involved in the safeguard of the oral cavity in children who have diabetes, as well as an higher concentration of the proinflammatory mediator S100A9* with respect to healthy children.
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