ReviewThe Journal of cell biology2010
Neighborly relations: cadherins and mechanotransduction.
Review in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension.Cellular and molecular life sciences : CMLS · 2024Article
- Role of angiomotin family members in human diseases (Review).Experimental and therapeutic medicine · 2024Review
- Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation.Frontiers in cell and developmental biology · 2022Article
- p73 as a Tissue Architect.Frontiers in cell and developmental biology · 2021Review
- Tumor spheroids under perfusion within a 3D microfluidic platform reveal critical roles of cell-cell adhesion in tumor invasion.Scientific reports · 2020Article
- Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling.Cells · 2019Review
- Multiscale and Multiaxial Mechanics of Vascular Smooth Muscle.Biophysical journal · 2017Article
- Biophysical Tools to Study Cellular Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation.Scientific reports · 2016Article
- Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels.The Journal of cell biology · 2015Article
- CDH2 and CDH11 act as regulators of stem cell fate decisions.Stem cell research · 2015Review
- Nuclear mechanotransduction: forcing the nucleus to respond.Nucleus (Austin, Tex.) · 2015Review
- Nuclear signaling from cadherin adhesion complexes.Current topics in developmental biology · 2015Review
- Adherens junction treadmilling during collective migration.Nature cell biology · 2014Article
- Mechanotransduction at the basis of endothelial barrier function.Tissue barriers · 2013Review
- Xin proteins and intercalated disc maturation, signaling and diseases.Frontiers in bioscience (Landmark edition) · 2012Review
- Epithelial protein lost in neoplasm (EPLIN) interacts with α-catenin and actin filaments in endothelial cells and stabilizes vascular capillary network in vitro.The Journal of biological chemistry · 2012Article
- Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?Journal of signal transduction · 2012Article
- Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.The Journal of cell biology · 2011Article
- Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.