ArticleToxicological sciences : an official journal of the Society of Toxicology2010
Genomic and proteomic responses to environmentally relevant exposures to dieldrin: indicators of neurodegeneration?
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- Polycystic ovary syndrome and organochlorine pesticides: exploring potential links and mechanisms.Frontiers in reproductive health · 2025Review
- Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer's disease.World journal of clinical cases · 2023Review
- Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Toxics · 2021Article
- Proteomic study of hypothalamus in pigs exposed to heat stress.BMC veterinary research · 2020Article
- Molecular Evolution and Characterization of Fish Stathmin Genes.Animals : an open access journal from MDPI · 2020Article
- Organochlorine pesticides: Agrochemicals with potent endocrine-disrupting properties in fish.Molecular and cellular endocrinology · 2020Review
- Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance.Frontiers in genetics · 2018Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides).Aquatic toxicology (Amsterdam, Netherlands) · 2014Article
- Infrared microspectroscopy identifies biomolecular changes associated with chronic oxidative stress in mammary epithelium and stroma of breast tissues from healthy young women: implications for latent stages of breast carcinogenesis.Cancer biology & therapy · 2014Article
- Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Sexually dimorphic transcriptomic responses in the teleostean hypothalamus: a case study with the organochlorine pesticide dieldrin.Neurotoxicology · 2013Article
- Quantitative proteomics in teleost fish: insights and challenges for neuroendocrine and neurotoxicology research.General and comparative endocrinology · 2012Review
- DIGE and iTRAQ as biomarker discovery tools in aquatic toxicology.Ecotoxicology and environmental safety · 2012Review
- Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA: implication for breast carcinogenesis.Cancer biology & therapy · 2012Article
- Effect-based tools for monitoring and predicting the ecotoxicological effects of chemicals in the aquatic environment.Sensors (Basel, Switzerland) · 2012Review
- An in vivo animal study assessing long-term changes in hypothalamic cytokines following perinatal exposure to a chemical mixture based on Arctic maternal body burden.Environmental health : a global access science source · 2011Article
- Neuroendocrine disruption: more than hormones are upset.Journal of toxicology and environmental health. Part B, Critical reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Dieldrin is a persistent organochlorine pesticide that induces neurotoxicity in the vertebrate central nervous system and impairs reproductive processes in fish. This study examined the molecular events produced by subchronic dietary exposures to 2.95 mg dieldrin/kg feed in the neuroendocrine brain of largemouth bass, an apex predator. Microarrays, proteomics, and pathway analysis were performed to identify genes, proteins, and cell processes altered in the male hypothalamus. Fifty-four genes were induced, and 220 genes were reduced in steady-state levels (p < 0.001; fold change greater than +/- 1.5). Functional enrichment analysis revealed that the biological gene ontology categories of stress response, nucleotide base excision repair, response to toxin, and metabolic processes were significantly impacted by dieldrin. Using isobaric tagging for relative and absolute quantitation, 90 proteins in the male hypothalamus were statistically evaluated for changes in protein abundance. Several proteins altered by dieldrin are known to be associated with human neurodegenerative diseases, including apolipoprotein E, microtubule-associated tau protein, enolase 1, stathmin 1a, myelin basic protein, and parvalbumin. Proteins altered by dieldrin were involved in oxidative phosphorylation, differentiation, proliferation, and cell survival. This study demonstrates that a subchronic exposure to dieldrin alters the abundance of messenger RNAs and proteins in the hypothalamus that are associated with cell metabolism, cell stability and integrity, stress, and DNA repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.