ArticleMolecular and cellular neurosciences2010
p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse.
Article in Molecular and cellular neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.Brain : a journal of neurology · 2025Article
- Astrocyte-Neuron Interactions in Spinal Cord Injury.Advances in neurobiology · 2024Review
- The functional and molecular roles of p75 neurotrophin receptor (p75Journal of central nervous system disease · 2024Review
- Long-distance regressive signaling in neural development and disease.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum,Frontiers in neuroanatomy · 2020Article
- p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Targeting skeletal endothelium to ameliorate bone loss.Nature medicine · 2018Article
- Common effects of attractive and repulsive signaling: Further analysis of Mical-mediated F-actin disassembly and regulation by Abl.Communicative & integrative biology · 2018Article
- Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.Stem cell reports · 2016Article
- Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity.Autonomic neuroscience : basic & clinical · 2015Review
- Low-intensity repetitive transcranial magnetic stimulation improves abnormal visual cortical circuit topography and upregulates BDNF in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.Development (Cambridge, England) · 2013Article
- Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes.Neoplasia (New York, N.Y.) · 2013Article
- Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve.Cell death & disease · 2013Article
- Of proneurotrophins and their antineurotrophic effects.Science signaling · 2013Review
- An activity-regulated microRNA, miR-188, controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.Science signaling · 2011Article
- Ephrin reverse signaling controls palate fusion via a PI3 kinase-dependent mechanism.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
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4 authors at 2 institutions in 1 country.
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Abstract
The p75 neurotrophin receptor (p75NTR) is required for the activity of growth cone collapsing factors such as Nogo, MAG, OMgP, and ephrin A. Specifically, p75NTR associates with the Nogo receptor and GPI-linked ephrin A, and unliganded p75NTR mediates the biological effects of those proteins. Here we assess the requirement for p75NTR for the growth cone collapsing responses of semaphorins (Sema) 3A and 3F and ephrin B2 in sympathetic neurons. We show that the ability of Sema 3s or ephrin B2 to collapse growth cones is suppressed in p75NTR-/- sympathetic neurons. Ectopic expression of p75NTR restores the collapsing activity of Sema 3 in p75NTR-/- neurons. Moreover, p75NTR must be bound to its neurotrophin ligands to participate in Sema 3-mediated collapse. Ligand-bound p75NTR participates in Sema 3 and ephrin B2-mediated collapse via the Rho signaling pathway, since inhibition of Rho signaling is sufficient to suppress the effects of Sema 3s and ephrin B2 in p75NTR+/+ but not p75NTR-/- neurons. Our data suggest that in addition to its role as a co-receptor, p75NTR may provide an obligate parallel neurotrophin-activated inhibitory pathway that broadly sensitizes neurons to inhibitory cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.