ArticleBiomaterials2010
The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 115 citations in OpenAlex.
- Microfluidic Production of Ultrathin, Handleable Collagen Sheets Exhibiting Toe-heel Tensile Behavior.Advanced materials technologies · 2025Article
- An Investigation of the Constructional Design Components Affecting the Mechanical Response and Cellular Activity of Electrospun Vascular Grafts.Membranes · 2022Review
- HuBiogel incorporated fibro-porous hybrid nanomatrix graft for vascular tissue interfaces.Materials today. Chemistry · 2020Article
- 3D Coaxial Bioprinting of Vasculature.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds.Tissue engineering. Part C, Methods · 2019Article
- Towards the directed evolution of protein materials.MRS communications · 2019Article
- Processing of collagen based biomaterials and the resulting materials properties.Biomedical engineering online · 2019Review
- Optimizing Blended Collagen-Fibrin Hydrogels for Cardiac Tissue Engineering with Human iPSC-derived Cardiomyocytes.ACS biomaterials science & engineering · 2019Article
- Fiber-reinforced scaffolds in soft tissue engineering.Regenerative biomaterials · 2017Review
- Tissue engineering-based therapeutic strategies for vocal fold repair and regeneration.Biomaterials · 2016Review
- Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers.Advanced healthcare materials · 2016Article
- Rational design of fiber forming supramolecular structures.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Advancing biomaterials of human origin for tissue engineering.Progress in polymer science · 2016Article
- Fabricated Elastin.Advanced healthcare materials · 2015Review
- Effective release of a broad spectrum antibiotic from elastin-like polypeptide-collagen composite.Journal of biomedical materials research. Part A · 2015Article
- In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits.Biomaterials science · 2015Article
- Effect of multiwall carbon nanotube reinforcement on coaxially extruded cellular vascular conduits.Materials science & engineering. C, Materials for biological applications · 2014Article
- Generation of spatially aligned collagen fiber networks through microtransfer molding.Advanced healthcare materials · 2014Article
- Microablation of collagen-based substrates for soft tissue engineering.Biomedical materials (Bristol, England) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Collagen and elastin networks contribute to highly specialized biomechanical responses in numerous tissues and species. Biomechanical properties such as modulus, elasticity, and strength ultimately affect tissue function and durability, as well as local cellular behavior. In the case of vascular bypass grafts, compliance at physiologic pressures is correlated with increased patency due to a reduction in anastomotic intimal hyperplasia. In this report, we combine extracellular matrix (ECM) protein analogues to yield multilamellar vascular grafts comprised of a recombinant elastin-like protein matrix reinforced with synthetic collagen microfibers. Structural analysis revealed that the fabrication scheme permits a range of fiber orientations and volume fractions, leading to tunable mechanical properties. Burst strengths of 239-2760 mm Hg, compliances of 2.8-8.4%/100 mm Hg, and suture retention strengths of 35-192 gf were observed. The design most closely approximating all target criteria displayed a burst strength of 1483 +/- 143 mm Hg, a compliance of 5.1 +/- 0.8%/100 mm Hg, and a suture retention strength of 173 +/- 4 gf. These results indicate that through incorporation of reinforcing collagen microfibers, recombinant elastomeric protein-based biomaterials can play a significant role in load bearing tissue substitutes. We believe that similar composites can be incorporated into tissue engineering schemes that seek to integrate cells within the structure, prior to or after implantation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.