ArticleHead & neck oncology2010
Methicillin Resistant Staphylococcus Aureus Infection as a causative agent of fistula formation following total laryngectomy for advanced head & neck cancer.
Article in Head & neck oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Predictive factors for the postlaryngectomy pharyngocutaneous fistula development: systematic review.Brazilian journal of otorhinolaryngology · 2014Pooled it
- Risk factors analysis and prediction model construction of LRTI in head and neck cancer patients with tracheostomy based on subglottic sputum aspiration volume.Frontiers in oral health · 2026Article
- Diagnosis of Genital Tuberculosis Unveiled by Utero-Cutaneous Fistula and Superimposed MRSA Infection: A Case Report.Infectious disorders drug targets · 2025Article
- Mapping the Risk Factors of Pharyngocutaneous Fistula After Salvage Laryngectomies.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Fascio-cutaneous-free flaps as primary reconstruction in salvage total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review.Annals of clinical microbiology and antimicrobials · 2020Review
- Bronchopleural phrenic fistula caused by methicillin-resistant staphylococcus aureus pneumonia.Journal of thoracic disease · 2018Article
- Pharyngo-jugular fistula after "salvage" total laryngectomy: a case report.Journal of medical case reports · 2015Article
- Time interval between primary radiotherapy and salvage laryngectomy: a predictor of pharyngocutaneous fistula formation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- Salvage surgery for head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- Post-operative wound infection in salvage laryngectomy: does antibiotic prophylaxis have an impact?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012Article
- Derivation of a clinical decision rule for predictive factors for the development of pharyngocutaneous fistula postlaryngectomy.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe purpose of this paper was to investigate the impact of Methicillin Resistant Staphylococcus Aureus (MRSA) infection in the aetiology of pharyngo-cutaneous fistula (PCF) formation following total laryngectomy for advanced laryngeal cancer.
methodsThis was a retrospective uncontrolled case study series of 31 consecutive patients based in a single institution tertiary referral head and neck oncology centre.
resultsPharyngo-cutaneous fistulas (PCF) following total laryngectomy occurred in 10 (32%) patients. MRSA was identified in 80% of patients with a PCF compared to 9% of patients that did not develop a fistula (p = 0.0001255 Fisher exact test). MRSA infection (p = 0.00012) and previous radiotherapy (p = 0.00025) were the only significant factors found to be important in fistula formation on multivariate analysis. Post-operative infections such as cellulitis, chest infection and carotid fistula were also associated with MRSA infections.
conclusionMRSA infection following total laryngectomy for laryngeal cancer can lead to potential serious complications such as PCF. Patients who underwent total laryngectomy following radiotherapy failure are at a higher risk of acquiring MRSA.
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Registered trials
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