ArticleBMC cancer2010
An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- A prognostic microRNA-based signature for localized clear cell renal cell carcinoma: the Bio-miR study.British journal of cancer · 2025Article
- Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer.International journal of genomics · 2021Article
- Computational models applied to metabolomics data hints at the relevance of glutamine metabolism in breast cancer.BMC cancer · 2020Article
- Genes and functions from breast cancer signatures.BMC cancer · 2018Article
- Reduced expression of SCUBE2 predicts poor prognosis in gastric cancer patients.International journal of clinical and experimental pathology · 2018Article
- Urothelial cancer proteomics provides both prognostic and functional information.Scientific reports · 2017Article
- Functional proteomics outlines the complexity of breast cancer molecular subtypes.Scientific reports · 2017Article
- Genetic Variation and Neuroplasticity: Role in Rehabilitation After Stroke.Journal of neurologic physical therapy : JNPT · 2017Review
- Prediction of adjuvant chemotherapy response in triple negative breast cancer with discovery and targeted proteomics.PloS one · 2017Article
- Gene signatures in breast cancer: current and future uses.Translational oncology · 2012Article
- MicroRNA expression profiling of peripheral blood samples predicts resistance to first-line sunitinib in advanced renal cell carcinoma patients.Neoplasia (New York, N.Y.) · 2012Article
- Testing an aflatoxin B1 gene signature in rat archival tissues.Chemical research in toxicology · 2012Article
- NCBI GEO: archive for functional genomics data sets--10 years on.Nucleic acids research · 2011Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant relapse.
methodsWe included 153 patients with stage I-II hormonal receptor-positive breast cancer. RNA was isolated from formalin-fixed paraffin-embedded samples and qRT-PCR amplification of 83 genes was performed with gene expression assays. The genes we analyzed were those included in the 70-Gene Signature, the Recurrence Score and the Two-Gene Index. The association among gene expression, clinical variables and distant metastasis-free survival was analyzed using Cox regression models.
resultsAn 8-gene prognostic score was defined. Distant metastasis-free survival at 5 years was 97% for patients defined as low-risk by the prognostic score versus 60% for patients defined as high-risk. The 8-gene score remained a significant factor in multivariate analysis and its performance was similar to that of two validated gene profiles: the 70-Gene Signature and the Recurrence Score. The validity of the signature was verified in independent cohorts obtained from the GEO database.
conclusionsThis study identifies a simple gene expression score that complements histopathological prognostic factors in breast cancer, and can be determined in paraffin-embedded samples.
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