SynthesisEnvironmental health : a global access science source2010
Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis.
Synthesis in Environmental health : a global access science source, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 248 citations in OpenAlex.
- Prevalence and associated factors of Leukemia in Africa: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Benzene Exposure and Lung Cancer Risk: A Systematic Review and Meta-Analysis of Human Studies.International journal of environmental research and public health · 2024Pooled it
- Association Between Job Characteristics, Benzene Exposure, and Hematopoietic Cancer Risk in Subway Maintenance Workers.Safety and health at work · 2026Article
- Review
- Chronic lymphatic leukaemia in a worker with a long-term occupational exposure to petroleum product mixtures: a case report.Arhiv za higijenu rada i toksikologiju · 2026Article
- Occupational Benzene Exposure and Hepatobiliary and Pancreatic Cancers: A Systematic Review and Meta-analysis.Safety and health at work · 2026Review
- Triptonide Suppresses AML via PI3K/AKT Signaling: A Network Pharmacology Approach Validated by Molecular Docking and Experimental Studies.Current issues in molecular biology · 2026Article
- Space-time clustering of childhood high hyperdiploid B-cell precursor acute lymphoblastic leukemia: a nationwide Swedish study.European journal of epidemiology · 2026Article
- The analysis of the leukemia mortality rate and its temporal trends in China from 2004 to 2021.BMC public health · 2026Article
- Leukemia disease burden and quality of care among adolescents and young adults in China compared to global patterns: a comprehensive analysis from 1990 to 2021.Frontiers in public health · 2026Article
- Benzene and human health: a comprehensive review of carcinogenic risks, mechanisms, and preventive strategies.Annals of medicine and surgery (2012) · 2025Review
- The burden dynamics of leukemia in China from 1990 to 2021: an epidemiological analysis of trends, risk factors, and projections to 2036.Preventive medicine reports · 2025Article
- Cardiac abnormalities induced by benzene exposure from the flaring disaster at the BP refinery plant in Texas City.International journal of occupational medicine and environmental health · 2025Article
- Spatial distribution of acute myeloid leukaemia in Denmark.Environmental health : a global access science source · 2025Article
- Rural-Urban Disparity in Premature Cancer Mortality in Young People Aged 15-44 Years in China, 2004-2021.International journal of public health · 2025Article
- Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Global, regional, and national burden of acute myeloid leukemia, 1990-2021: a systematic analysis for the global burden of disease study 2021.Biomarker research · 2024Article
- Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells.Toxics · 2024Article
- Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia.International journal of molecular sciences · 2024Review
- How Government Health Agencies Obscure the Impact of Environmental Pollution and Perpetuate Reductionist Framings of Disease: The Case of Leukemia.International journal of social determinants of health and health services · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA substantial number of epidemiologic studies have provided estimates of the relation between exposure to benzene at work and the risk of leukemia, but the results have been heterogeneous. To bridge this gap in knowledge, we synthesized the existing epidemiologic evidence on the relation between occupational exposure to benzene and the risk of leukemia, including all types combined and the four main subgroups acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).
methodsA systematic literature review was carried out using two databases 'Medline' and 'Embase' from 1950 through to July 2009. We selected articles which provided information that can be used to estimate the relation between benzene exposure and cancer risk (effect size).
resultsIn total 15 studies were identified in the search, providing 16 effect estimates for the main analysis. The summary effect size for any leukemia from the fixed-effects model was 1.40 (95% CI, 1.23-1.57), but the study-specific estimates were strongly heterogeneous (I2 = 56.5%, Q stat = 34.47, p = 0.003). The random-effects model yielded a summary- effect size estimate of 1.72 (95% CI, 1.37-2.17). Effect estimates from 9 studies were based on cumulative exposures. In these studies the risk of leukemia increased with a dose-response pattern with a summary-effect estimate of 1.64 (95% CI, 1.13-2.39) for low (< 40 ppm-years), 1.90 (95% CI, 1.26-2.89) for medium (40-99.9 ppm-years), and 2.62 (95% CI, 1.57-4.39) for high exposure category (> 100 ppm-years). In a meta-regression, the trend was statistically significant (P = 0.015). Use of cumulative exposure eliminated heterogeneity. The risk of AML also increased from low (1.94, 95% CI, 0.95-3.95), medium (2.32, 95% CI, 0.91-5.94) to high exposure category (3.20, 95% CI, 1.09-9.45), but the trend was not statistically significant.
conclusionsOur study provides consistent evidence that exposure to benzene at work increases the risk of leukemia with a dose-response pattern. There was some evidence of an increased risk of AML and CLL. The meta-analysis indicated a lack of association between benzene exposure and the risk of CML.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.