ArticleBMC genetics2010
Detection of quantitative trait loci affecting haematological traits in swine via genome scanning.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Multivariate genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2023Article
- Assessment of Hematologic and Biochemical Parameters for Healthy Commercial Pigs in China.Animals : an open access journal from MDPI · 2022Article
- Article
- Genotype-by-environment interactions for reproduction, body composition, and growth traits in maternal-line pigs based on single-step genomic reaction norms.Genetics, selection, evolution : GSE · 2021Article
- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- Transcriptional Profiling of Leucocyte Count Variation from Porcine Peripheral Blood Reveals Differential Gene Expression.BioMed research international · 2018Article
- Hematology and biochemistry reference intervals for Ontario commercial nursing pigs close to the time of weaning.The Canadian veterinary journal = La revue veterinaire canadienne · 2017Article
- Single- and Bayesian Multi-Marker Genome-Wide Association for Haematological Parameters in Pigs.PloS one · 2016Article
- QTL affecting stress response to crowding in a rainbow trout broodstock population.BMC genetics · 2012Article
- Genome-wide association study of porcine hematological parameters in a Large White × Minzhu F2 resource population.International journal of biological sciences · 2012Article
- Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine.BMC genetics · 2011Article
- The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Journal of thrombosis and haemostasis : JTH · 2011Review
- Prediction of disease and phenotype associations from genome-wide association studies.PloS one · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHaematological traits, which consist of mainly three components: leukocyte traits, erythrocyte traits and platelet traits, play extremely important role in animal immune function and disease resistance. But knowledge of the genetic background controlling variability of these traits is very limited, especially in swine.
resultsIn the present study, 18 haematological traits (7 leukocyte traits, 7 erythrocyte traits and 4 platelet traits) were measured in a pig resource population consisting of 368 purebred piglets of three breeds (Landrace, Large White and Songliao Black Pig), after inoculation with the swine fever vaccine when the pigs were 21 days old. A whole-genome scan of QTL for these traits was performed using 206 microsatellite markers covering all 18 autosomes and the X chromosome. Using variance component analysis based on a linear mixed model and the false discovery rate (FDR) test, 35 QTL with FDR < 0.10 were identified: 3 for the leukocyte traits, 28 for the erythrocyte traits, and 4 for the platelet traits. Of the 35 QTL, 25 were significant at FDR < 0.05 level, including 9 significant at FDR < 0.01 level.
conclusionsVery few QTL were previously identified for hematological traits of pigs and never in purebred populations. Most of the QTL detected here, in particular the QTL for the platelet traits, have not been reported before. Our results lay important foundation for identifying the causal genes underlying the hematological trait variations in pigs.
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