ArticleBMC complementary and alternative medicine2010
Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea.
Article in BMC complementary and alternative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Ethnobotany, phytochemistry, and biological activities ofFrontiers in pharmacology · 2024Pooled it
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- Ethnomedicinal Survey of Plants Used for Treatment of Mild COVID-19-Related Symptoms in Gorontalo Province, Indonesia.Scientifica · 2025Article
- Amazonian useful plants described in the book "Le Pays des Amazones" (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective.Journal of ethnobiology and ethnomedicine · 2024Article
- A scoping review on efficacy and safety of medicinal plants used for the treatment of diarrhea in sub-Saharan Africa.Tropical medicine and health · 2024Article
- Development of the paper-based colorimetric sensor for simple and fast determination of quercetin in guava leaf extract.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- Ayurveda management of pulmonary mycosis: an integrative approach: a case report.Journal of medical case reports · 2023Article
- Anti-Cholera toxin activity of selected polyphenols fromFrontiers in cellular and infection microbiology · 2023Article
- Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms.BioMed research international · 2023Review
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- A review on anti-peptic ulcer activities of medicinal plants used in the formulation ofHeliyon · 2021Review
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- Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice.Frontiers in veterinary science · 2021Article
- The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Simultaneous Determination of α-Glucosidase Inhibitory Triterpenoids inMolecules (Basel, Switzerland) · 2020Article
- Evaluation of Acute and Subacute Toxicities ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Anti-infective efficacy ofF1000Research · 2019Article
- An ethno-pharmacological study of plants used for traditional medication in Tangail district, Bangladesh.Electronic physician · 2017Article
- Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade.International journal of molecular sciences · 2017Review
- Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera.African health sciences · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsidium guajava L., Myrtaceae, is used widely in traditional medicine for the treatment of diarrhoea, dysentery, gastroenteritis, stomachaches, and indigestion. However, the effect of the leaf extract of P. guajava on the pathogenesis of infectious diarrhoea has not been studied. The present study evaluates the effect of a hot aqueous extract (decoction) of dried leaves of P. guajava on parameters associated with pathogenicity of infectious diarrhoea. The aim was to understand its possible mechanism(s) of action in controlling infectious diarrhoea and compare it with quercetin, one of the most reported active constituents of P. guajava with antidiarrhoeal activity.
methodsThe crude decoction and quercetin were studied for their antibacterial activity and effect on virulence features of common diarrhoeal pathogens viz. colonization of epithelial cells and production and action of enterotoxins. Colonization as measured by adherence of enteropathogenic Escherichia coli (EPEC) and invasion of enteroinvasive E. coli (EIEC) and Shigella flexneri was assessed using HEp-2 cell line. The production of E. coli heat labile toxin (LT) and cholera toxin (CT) and their binding to ganglioside monosialic acid (GM1) were studied by GM1-ELISA whereas the production and action of E. coli heat stable toxin (ST) was assessed by suckling mouse assay.
resultsThe decoction of P. guajava showed antibacterial activity towards S. flexneri and Vibrio cholerae. It decreased production of both LT and CT and their binding to GM1. However, it had no effect on production and action of ST. The decoction also inhibited the adherence of EPEC and invasion by both EIEC and S. flexneri to HEp-2 cells. Quercetin, on the other hand, had no antibacterial activity at the concentrations used nor did it affect any of the enterotoxins. Although it did not affect adherence of EPEC, it inhibited the invasion of both EIEC and S. flexneri to HEp-2 cells.
conclusionCollectively, the results indicate that the decoction of P. guajava leaves is an effective antidiarrhoeal agent and that the entire spectrum of its antidiarrhoeal activity is not due to quercetin alone.
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