ArticleThe Annals of otology, rhinology, and laryngology2010
Biosimulation of inflammation and healing in surgically injured vocal folds.
Article in The Annals of otology, rhinology, and laryngology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Biosimulation of acute phonotrauma: an extended model.The Laryngoscope · 2011Trial
- Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025Review
- An integrated empirical and computational study to decipher help-seeking behaviors and vocal stigma.Communications medicine · 2024Article
- Agent-based models of inflammation in translational systems biology: A decade later.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification.Applied sciences (Basel, Switzerland) · 2019Article
- High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair.Frontiers in physiology · 2018Article
- Cellular source and proinflammatory roles of high-mobility group box 1 in surgically injured rat vocal folds.The Laryngoscope · 2017Article
- Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.Annals of biomedical engineering · 2016Review
- Real-Time Agent-Based Modeling Simulation with in-situ Visualization of Complex Biological Systems: A Case Study on Vocal Fold Inflammation and Healing.IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum : [proceedings]. IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum · 2016Article
- Classification for animal vocal fold surgery: resection margins impact histological outcomes of vocal fold injury.The Laryngoscope · 2014Article
- Dose-dependent effect of mitomycin C on human vocal fold fibroblasts.Head & neck · 2014Article
- Using an Agent-Based Model to Examine the Role of Dynamic Bacterial Virulence Potential in the Pathogenesis of Surgical Site Infection.Advances in wound care · 2013Article
- Computational Modeling of Inflammation and Wound Healing.Advances in wound care · 2013Article
- Translational applications of evaluating physiologic variability in human endotoxemia.Journal of clinical monitoring and computing · 2013Review
- Current Understanding and Future Directions for Vocal Fold Mechanobiology.Journal of cytology & molecular biology · 2013Article
- A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks.PloS one · 2011Article
- Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models.Current opinion in otolaryngology & head and neck surgery · 2010Review
- Translational systems biology of inflammation: potential applications to personalized medicine.Personalized medicine · 2010Article
- High-Performance Host-Device Scheduling and Data-Transfer Minimization Techniques for Visualization of 3D Agent-Based Wound Healing Applications.PDPTA '19 : proceedings of the 2019 International Conference on Parallel & Distributed Processing Techniquess & Applications. International Conference on Parallel and Distributed Processing Techniques and Applications (2019 : Las Vegas,...Article
- In Situ Visualization for 3D Agent-Based Vocal Fold Inflammation and Repair Simulation.Supercomputing frontiers and innovationsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe pathogenesis of vocal fold scarring is complex and remains to be deciphered. The current study is part of research endeavors aimed at applying systems biology approaches to address the complex biological processes involved in the pathogenesis of vocal fold scarring and other lesions affecting the larynx.
methodsWe developed a computational agent-based model (ABM) to quantitatively characterize multiple cellular and molecular interactions involved in inflammation and healing in vocal fold mucosa after surgical trauma. The ABM was calibrated with empirical data on inflammatory mediators (eg, tumor necrosis factor) and extracellular matrix components (eg, hyaluronan) from published studies on surgical vocal fold injury in the rat population.
resultsThe simulation results reproduced and predicted trajectories seen in the empirical data from the animals. Moreover, the ABM studies suggested that hyaluronan fragments might be the clinical surrogate of tissue damage, a key variable that in these simulations both is enhanced by and further induces inflammation.
conclusionsA relatively simple ABM such as the one reported in this study can provide new understanding of laryngeal wound healing and generate working hypotheses for further wet-lab studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.