ReviewJournal of molecular neuroscience : MN2011
Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists.
Review in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Lateral hypothalamic melanin concentrating hormone-expressing neurons both promote and are required for cue-potentiated feeding.Journal of neuroendocrinology · 2026Article
- The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.British journal of pharmacology · 2025Review
- An Electroencephalogram Signature of Melanin-Concentrating Hormone Neuron Activities Predicts Cocaine Seeking.Biological psychiatry · 2024Article
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.Cell discovery · 2024Article
- An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking.bioRxiv : the preprint server for biology · 2024Article
- Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130.Journal of bioenergetics and biomembranes · 2023Article
- The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.British journal of pharmacology · 2023Article
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Rapid Eye Movement Sleep Engages Melanin-Concentrating Hormone Neurons to Reduce Cocaine Seeking.Biological psychiatry · 2022Article
- Anxiety and Depression: What Do We Know of Neuropeptides?Behavioral sciences (Basel, Switzerland) · 2022Review
- Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior.Scientific reports · 2021Article
- The Melanin-concentrating Hormone System in Human, Rodent and Avian Brain.Open medicine (Warsaw, Poland) · 2018Article
- Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response.Current neuropharmacology · 2018Review
- Melanin concentrating hormone modulates oxytocin-mediated marble burying.Neuropharmacology · 2018Article
- Lef1-dependent hypothalamic neurogenesis inhibits anxiety.PLoS biology · 2017Article
- Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders.Current psychiatry reports · 2015Review
- Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.British journal of pharmacology · 2015Article
- Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression.Frontiers in neuroscience · 2015Review
- The melanin-concentrating hormone receptors: neuronal and non-neuronal functions.International journal of obesity supplements · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Melanin-concentrating hormone (MCH) is a 19-amino-acid cyclic peptide which was originally found to lighten skin color in fish that is highly conserved among many species. MCH interacts with two G-protein-coupled receptors, MCH1R and MCH2R, but only MCH1R is expressed in rodents. MCH is mainly synthesized in the lateral hypothalamus and zona incerta, while MCH1R is widely expressed throughout the brain. Thus, MCH signaling is implicated in the regulation of many physiological functions. The identification of MCH1R has led to the development of small-molecule MCH1R antagonists that can block MCH signaling. MCH1R antagonists are useful not only for their potential therapeutic value, but also for understanding the physiological functions of the endogenous MCH system. Here, we review the physiological functions of the MCH system which have been investigated using MCH1R antagonists such as food intake, anxiety, depression, reward, and sleep. This will help us understand the physiological functions of the MCH system and suggest some of the potential applications of MCH1R antagonists in human disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.