Trial reportJournal of neurology2010
Subthalamic nucleus deep brain stimulation changes speech respiratory and laryngeal control in Parkinson's disease.
Trial report in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta-analysis.Movement disorders : official journal of the Movement Disorder Society · 2026Pooled it
- Subthalamic nucleus deep brain stimulation changes velopharyngeal control in Parkinson's disease.Journal of communication disordersTrial
- Intensive voice treatment (LSVT®LOUD) for Parkinson's disease following deep brain stimulation of the subthalamic nucleus.Journal of communication disordersTrial
- Improved oxygen saturation after deep brain stimulation in Parkinson's disease.Neurosurgical review · 2025Article
- Effects of Deep-Brain Stimulation on Speech: Perceptual and Acoustic Data.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Effects of speech rate modifications on phonatory acoustic outcomes in Parkinson's disease.Frontiers in human neuroscience · 2024Article
- Article
- Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation.Frontiers in pharmacology · 2023Article
- Respiratory dysfunction in Parkinson's disease: a narrative review.ERJ open research · 2020Review
- Anterior Sensorimotor Subthalamic Nucleus Stimulation Is Associated With Improved Voice Function.Neurosurgery · 2020Article
- Acoustic Voice Modifications in Individuals with Parkinson Disease Submitted to Deep Brain Stimulation.International archives of otorhinolaryngology · 2019Article
- Relationship Between Respiratory Sensory Perception, Speech, and Swallow in Parkinson's Disease.Movement disorders clinical practice · 2019Article
- Rapid Alleviation of Parkinson's Disease Symptoms via Electrostimulation of Intrinsic Auricular Muscle Zones.Frontiers in human neuroscience · 2017Article
- Effects of deep brain stimulation on vocal fold immobility in Parkinson's disease.Surgical neurology international · 2017Article
- Adverse events in deep brain stimulation: A retrospective long-term analysis of neurological, psychiatric and other occurrences.PloS one · 2017Article
- Subcortical Effects on Voice and Fluency in Dysarthria: Observations from Subthalamic Nucleus Stimulation.Journal of Alzheimer's disease & Parkinsonism · 2017Article
- Evaluation, treatment, and analysis of a rare case of motor speech systems dyscoordination syndrome.Cogent medicine · 2017Article
- Subthalamic Stimulation Reduces Vowel Space at the Initiation of Sustained Production: Implications for Articulatory Motor Control in Parkinson's Disease.Journal of Parkinson's disease · 2016Article
- Sensory contribution to vocal emotion deficit in Parkinson's disease after subthalamic stimulation.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
- Aerodynamic assessment of phonatory onset in Parkinson's disease: evidence of decreased scaling of laryngeal and respiratory control.Journal of Parkinson's disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Adequate respiratory and laryngeal motor control are essential for speech, but may be impaired in Parkinson's disease (PD). Bilateral subthalamic nucleus deep brain stimulation (STN DBS) improves limb function in PD, but the effects on respiratory and laryngeal control remain unknown. We tested whether STN DBS would change aerodynamic measures of respiratory and laryngeal control, and whether these changes were correlated with limb function and stimulation parameters. Eighteen PD participants with bilateral STN DBS were tested within a morning session after a minimum of 12 h since their most recent dose of anti-PD medication. Testing occurred when DBS was on, and again 1 h after DBS was turned off, and included aerodynamic measures during syllable production, and standard clinical ratings of limb function. We found that PD participants exhibited changes with DBS, consistent with increased respiratory driving pressure (n = 9) and increased vocal fold closure (n = 9). However, most participants exceeded a typical operating range for these respiratory and laryngeal control variables with DBS. Changes were uncorrelated with limb function, but showed some correlation with stimulation frequency and pulse width, suggesting that speech may benefit more from low-frequency stimulation and shorter pulse width. Therefore, high-frequency STN DBS may be less beneficial for speech-related respiratory and laryngeal control than for limb motor control. It is important to consider these distinctions and their underlying mechanisms when assessing the impact of STN DBS on PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.